2023年4月第30卷第4期沙库巴曲缬沙坦联合美托洛尔治疗慢性射血分数降低心力衰竭的临床效果及对患者心功能的影响李冬丽，刘冬艳（郑州市金水区总医院内科，河南郑州450040）【摘要】目的探讨沙库巴曲缬沙坦联合美托洛尔治疗慢性射血分数降低心力衰竭（HFrEF）的临床效果及对患者心功能的影响。方法86例慢性HFrEF患者随机分为两组。在常规治疗基础上，对照组采用美托洛尔治疗，观察组采用沙库巴曲缬沙坦联合美托洛尔治疗。比较两组的临床疗效及治疗前后的心功能指标（LVEF、LVESd）。结果治疗2个月后，观察组的治疗总有效率为93．02％，高于对照组的76．74％（P＜0．05）。治疗2个月后，两组的LVEF均高于治疗前，LVESd均低于治疗前（P＜0．05）；且与对照组相比，观察组的LVEF显著更高，LVESd显著更低（P＜0．05）。结论沙库巴曲缬沙坦联合美托洛尔治疗慢性HFrEF可显著改善患者心功能，提升临床疗效。【关键词】慢性射血分数降低心力衰竭；沙库巴曲缬沙坦；美托洛尔；心功能中图分类号：R541.6文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0485ClinicalEffectofSacubitrilValsartanCombinedwithMetoprololintheTreatmentofChronicHeartFailurewithReducedEjectionFractionandItsImpactonCardiacFunctionofPatientsLIDongli,LIUDongyan(DepartmentofInternalMedicine,JinshuiDistrictGeneralHospital,Zhengzhou450040,China)[Abstract]ObjectiveToexploretheclinicaleffectofsacubitrilvalsartancombinedwithmetoprololinthetreatmentofchronicheartfailurewithreducedejectionfraction(HFrEF)anditsimpactoncardiacfunctionofpatients.Methods86patientswithchronicHFrEFwererandomlydividedintotwogroups.Onthebasisofconventionaltherapy,thecontrolgroupwastreatedwithmetoprolol,andtheobservationgroupwastreatedwithsacubitrilvalsartancombinedwithmetoprolol.Theclinicalefficacy,andthecardiacfunctionindicators(LVEF,LVESd)beforeandaftertreatmentwerecomparedbetweenthetwogroups.ResultsAfter2monthsoftreatment,thetotaleffectiverateoftheobservationgroupwas93.02%,higherthan76.74%ofthecontrolgroup(P<0.05).After2monthsoftreatment,LVEFinbothgroupswerehigherthanthosebeforetreatment,andLVESdwerelowerthanthosebeforetreatment(P<0.05);Comparedwiththecontrolgroup,theLVEFoftheobservationgroupwassignificantlyhi...
