2023年4月第30卷第4期不同剂量沙库巴曲缬沙坦对缺血性心肌病患者心室重构的影响杨晓凯1，肖丽丽2（濮阳仁济医院1内科，2彩超室，河南濮阳457100）【摘要】目的探讨不同剂量沙库巴曲缬沙坦对缺血性心肌病患者心室重构的影响。方法50例缺血性心肌病患者随机分为两组，对照组应用常规剂量沙库巴曲缬沙坦治疗，观察组应用低剂量沙库巴曲缬沙坦治疗，比较两组的治疗效果、心室重构指标及不良反应。结果两组的总有效率比较，差异无统计学意义（P＞0．05）。治疗后，两组的LVMI、LVRI、RVEDV及RVESV水平均低于治疗前（P＜0．05），但两组的LVMI、LVRI、RVEDV及RVESV水平比较，差异均无统计学意义（P＞0．05）。观察组的不良反应总发生率低于对照组（P＜0．05）。结论低剂量沙库巴曲缬沙坦治疗缺血性心肌病可获得与常规剂量相当的临床效果，可有效改善心室重构，且安全性更高。【关键词】不同剂量；沙库巴曲缬沙坦；缺血性心肌病；心室重构；安全性中图分类号：R542.2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0473ImpactofDifferentDosesofSacubitrilValsartanonVentricularRemodelingofPatientswithIschemicCardiomyopathyYANGXiaokai1,XIAOLili2(1DepartmentofInternalMedicine,2ColorDopplerUltrasoundRoom,PuyangRenjiHospital,Puyang457100,China)[Abstract]ObjectiveToexploretheimpactofdifferentdosesofsacubitrilvalsartanonventricularremodelingofpatientswithischemiccardiomyopathy.Methods50patientswithischemiccardiomyopathywererandomlydividedintotwogroups.Thecontrolgroupwastreatedwithconventionaldoseofsacubitrilvalsartan,andtheobservationgroupwastreatedwithlowdoseofsacubitrilvalsartan.Thetherapeuticeffect,ventricularremodelingindicatorsandadversereactionswerecomparedbetweenthetwogroups.ResultsNosignificantdifferencewasfoundinthetotaleffectiveratebetweenthetwogroups(P>0.05).Aftertreatment,thelevelsofLVMI,LVRI,RVEDVandRVESVinthetwogroupswerelowerthanthosebeforetreatment(P<0.05),whilenosignificantdifferencewasfoundinthelevelsofLVMI,LVRI,RVEDVandRVESVbetweenthetwogroups(P>0.05).Thetotalincidenceofadversereactionsintheobservationgroupwaslowerthanthatinthecontrolgroup(P<0.05).ConclusionsLow-dosesacubitrilvalsartaninthetreatmentofischemiccardiomyopathycanachieve...
