药物与临床药物与临床China&ForeignMedicalTreatment中外医疗2024NO.7中外医疗China&ForeignMedicalTreatment沙库巴曲缬沙坦钠对心力衰竭伴低钠血症患者心功能及血钠水平的影响黄小春东台市中医院心血管内科，江苏盐城224200［摘要］目的探讨沙库巴曲缬沙坦钠治疗心力衰竭伴低钠血症患者的意义以及对患者心功能和血钠水平的效果。方法方便选取2020年6月—2022年12月东台市中医院收治的112例心力衰竭伴低钠血症患者作为研究对象，根据摸球法分为两组，每组56例。对照组用依那普利进行治疗；观察组用沙库巴曲缬沙坦钠进行治疗。对比两组的治疗效果、心功能改善情况及相关血钠指标变化。结果观察组的治疗总有效率（98.21%）高于对照组（87.50%），差异有统计学意义（χ2=4.846，P<0.05）。观察组的心功能指标、6min步行距离均优于对照组，差异有统计学意义（P均<0.05）。观察组生化指标均优于对照组，差异统计学意义（P<0.05）。结论沙库巴曲缬沙坦钠在心力衰竭伴低钠血症患者中疗效更为确切，在改善患者心功能和血钠中均有突出作用。［关键词］心力衰竭伴低钠血症；心功能；血钠；沙库巴曲缬沙坦钠［中图分类号］R541［文献标识码］A［文章编号］1674-0742（2024）03(a)-0105-04EffectofSacubitrilValsartanSodiumonCardiacFunctionandBloodSo⁃diumLevelinPatientswithHeartFailureandHyponatremiaHUANGXiaochunDepartmentofCardiovascularMedicine,DongtaiHospitalofTraditionalChineseMedicine,Yancheng,JiangsuProv⁃ince,224200China[Abstract]ObjectiveToinvestigatethesignificanceofsacubitrilvalsartansodiuminthetreatmentofpatientswithheartfailureandhyponatremiaandtheeffectoncardiacfunctionandbloodsodiumlevel.MethodsAtotalof112pa⁃tientswithheartfailureandhyponatremiaadmittedtoDongtaiHospitalofTraditionalChineseMedicinefromJune2020toDecember2022wereconvenientlyselectedasthestudyobjects.Thepatientsweredividedintotwogroupsac⁃cordingtoball-touchmethod,with56casesineachgroup.Thecontrolgroupwastreatedwithenalapril,andtheob⁃servationgroupwastreatedwithsacubitrilvalsartansodium.Thetherapeuticeffect,theimprovementofcardiacfunc⁃tionandthechangesofbloodsodiumindexwerecomparedbetweenthetwogroups.ResultsThetotaleffectiverateofobservationgroup(98.21%)washigherthanthatofcontrolgroup(87....
