AcceptedManuscriptTitle:CurrentandupcomingmitochondrialtargetsforcancertherapyAuthors:HyoungKyuKim,YeonHeeNoh,BerndNilius,KyungSooKo,ByoungDooRhee,NariKim,JinHanPII:S1044-579X(17)30157-8DOI:http://dx.doi.org/doi:10.1016/j.semcancer.2017.06.006Reference:YSCBI1347Toappearin:SeminarsinCancerBiologyReceiveddate:16-11-2016Reviseddate:1-6-2017Accepteddate:9-6-2017Pleasecitethisarticleas:KimHyoungKyu,NohYeonHee,NiliusBernd,KoKyungSoo,RheeByoungDoo,KimNari,HanJin.Currentandupcomingmitochondrialtargetsforcancertherapy.SeminarsinCancerBiologyhttp://dx.doi.org/10.1016/j.semcancer.2017.06.006ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.1CurrentandupcomingmitochondrialtargetsforcancertherapyHyoungKyuKim1,2,YeonHeeNoh1,BerndNilius3,KyungSooKo1,ByoungDooRhee1,NariKim1,andJinHan1*1NationalResearchLaboratoryforMitochondrialSignaling,DepartmentofPhysiology,DepartmentofHealthSciencesandTechnology,BK21plusProjectTeam,CollegeofMedicine,CardiovascularandMetabolicDiseaseCenter,InjeUniversity,Busan,Korea2DepartmentofIntegratedBiomedicalScience,CollegeofMedicine,InjeUniversity,Busan,Korea3KULeuven,DepartmentCellMolMedicine,Leuven,3000,Belgium*Correspondingauthor:JinHan(e-mail:phyhanj@inje.ac.kr),NationalResearchLaboratoryforMitochondrialSignaling,DepartmentofPhysiology,CardiovascularandMetabolicDiseaseCenter,CollegeofMedicine,InjeUniversity,Bokji-ro75,Busanjin-gu,Busan47392,Korea.(Tel)82-51-890-6727,(Fax)82-51-894-5714AbstractMitochondriaareessentialintracellularorganellesthatregulateenergymetabolism,celldeath,andsignalingpathwaysthatareimportantforcellproliferationanddifferentiation.Therefore,mitochondriaarefundamentallyimplicatedincancerbiology,inc...
