ArticleHumanEpistaticInteractionControlsIL7RSplicingandIncreasesMultipleSclerosisRiskGraphicalAbstractHighlightsdDDX39BisapotentactivatorofIL7Rexon6splicingandarepressorofsIL7RdDDX39BgeneticvariantsaresignificantlyassociatedwithMSriskdThe50UTRDDX39BvariantreducesproteinlevelsbydecreasingtranslationefficiencydThisvariantshowsstronggeneticandfunctionalepistasiswithIL7Rrs6897932AuthorsGaddielGalarza-Mun˜oz,FarrenB.S.Briggs,IrinaEvsyukova,...,LisaF.Barcellos,SimonG.Gregory,MarianoA.Garcia-BlancoCorrespondencesimon.gregory@duke.edu(S.G.G.),maragarc@utmb.edu(M.A.G.-B.)InBriefTwogenesinteractepistaticallyinmultiplesclerosisriskinhumans.Galarza-Mun˜ozetal.,2017,Cell169,72–84March23,2017ª2017ElsevierInc.http://dx.doi.org/10.1016/j.cell.2017.03.007ArticleHumanEpistaticInteractionControlsIL7RSplicingandIncreasesMultipleSclerosisRiskGaddielGalarza-Mun˜oz,1,2,3FarrenB.S.Briggs,4IrinaEvsyukova,2GeraldineSchott-Lerner,3EdwardM.Kennedy,1TinasheNyanhete,5,6LiuyangWang,1LauraBergamaschi,7StevenG.Widen,3GeorgiaD.Tomaras,1,5,6DennisC.Ko,1,8SheltonS.Bradrick,1,2,3LisaF.Barcellos,9SimonG.Gregory,7,10,11,*andMarianoA.Garcia-Blanco1,2,3,11,12,*1DepartmentofMolecularGeneticsandMicrobiology,DukeUniversityMedicalCenter,Durham,NC27710,USA2CenterforRNABiology,DukeUniversity,Durham,NC27710,USA3DepartmentofBiochemistryandMolecularBiology,UniversityofTexasMedicalBranch,Galveston,TX77555,USA4DepartmentofEpidemiologyandBiostatistics,SchoolofMedicine,CaseWesternReserveUniversity,Cleveland,OH44106,USA5DepartmentofImmunology,DukeUniversityDurham,NC27710,USA6DepartmentofSurgery,DukeUniversityDurham,NC27710,USA7DukeMolecularPhysiologyInstitute,DukeUniversity,Durham,NC27701,USA8DepartmentofMedicine,DukeUniversityMedicalCenter;Durham,NC27710,USA9DivisionofEpidemiology,SchoolofPublicHealth,UniversityofCaliforniaBerkeley,Berkeley,CA94720,USA10DepartmentofNeurology,DukeUniversityMedicalCenter,Durham,NC27710,USA11Theseauthorscontributedequally12LeadContact*Correspondence:simon.gregory@duke.edu(S.G.G.),...
