IFNγ-DependentTissue-ImmuneHomeostasisIsCo-optedintheTumorMicroenvironmentChristopherJ.Nirschl1,25,MayteSuárez-Fariñas2,3,4,25,BenjaminIzar5,6,7,SanjayPrakadan5,8,9,RuthDannenfelser10,11,ItayTirosh5,YongLiu1,QianZhu10,11,K.SanjanaP.Devi1,ShainaL.Carroll5,8,9,DavidChau1,MelikaRezaee12,Tae-GyunKim1,RuiqiHuang3,JudilynFuentes-Duculan13,GeorgeX.Song-Zhao1,NicholasGulati13,MichelleA.Lowes13,SandraL.King1,FranciscoJ.Quintana5,14,Young-sukLee10,11,JamesG.Krueger13,KavitaY.Sarin12,CharlesH.Yoon15,16,LeviGarraway5,6,7,17,18,AvivRegev5,18,19,AlexK.Shalek5,8,9,20,21,OlgaTroyanskaya10,11,22,andNiroshanaAnandasabapathy1,23,24,261DepartmentofDermatology,BrighamandWomen'sHospital,HarvardMedicalSchool,Boston,MA02115,USA2DepartmentofDermatology,MountSinaiSchoolofMedicine,NY,NY10029,USA3DepartmentofGeneticsandGenomicsSciencesMountSinaiSchoolofMedicine,NY,NY10029USA4PopulationHealthScienceandPolicy,MountSinaiSchoolofMedicine,NY,NY10029,USA5BroadInstituteofMITandHarvard,Cambridge,MA02142,USA6DepartmentofMedicalOncology,Dana-FarberCancerInstitute,HarvardMedicalSchool,Boston,MA02215,USA7CenterforCancerPrecisionMedicine,Dana-FarberCancerInstitute,Boston,MA02215,USA8InstituteforMedicalEngineeringandScienceandDepartmentofChemistry,MIT,Cambridge,MA02139,USA9RagonInstituteofMIT,Harvard,andMGH,Cambridge,MA02139,USA10DepartmentofComputerScience,PrincetonUniversity,Princeton,NJ08540,USA11Lewis-SiglerInstituteforIntegrativeGenomics,PrincetonUniversity,Princeton,NJ08540,USA12DepartmentofDermatology,StanfordUniversity,Stanford,CA94305,USA13LaboratoryforInvestigativeDermatology,RockefellerUniversity.NewYork,NY10065,USACorrespondenceto:NiroshanaAnandasabapathy.25Theseauthorscontributedequally26LeadContactSupplementalInformation:SupplementalInformationincludessevenfigures,seventables,andonedatafileandcanbefoundwiththisarticleonlineathttp://dx.doi.org/10.1016/j.cell.2017.06.016.AuthorContributions:Conceptualization:N.A.,M.S.-F.,O.T.,I.T.,A.K.S.,M.A.L.,K.Y.S.,C.H.Y.Methodology:N.A.,M.S.-F.,C.J.N.,...