FatemappingofhumanglioblastomarevealsaninvariantstemcellhierarchyXiaoyangLan1,2,3,DavidJ.Jörg4,5,FlorenceM.G.Cavalli1,2,LauraM.Richards12,13,LongV.Nguyen7,RobertJ.Vanner1,2,3,PaulGuilhamon12,13,14,LilianLee1,2,MichelleKushida1,2,DavidePellacani7,8,NicoleI.Park1,2,3,FionaJ.Coutinho1,2,3,HeatherWhetstone1,2,HaydenJ.Selvadurai1,2,ClareChe1,2,BettyLuu1,2,AnnaickCarles9,MichelleMoksa9,NaghmehRastegar1,2,ReneeHead1,2,SonamDolma1,2,11,PanagiotisPrinos13,20,MichaelD.Cusimano17,18,SunitDas17,18,MarkBernstein16,18,CherylH.Arrowsmith13,20,AndrewJ.Mungall10,RichardA.Moore10,YussanneMa10,MarcoGallo19,MathieuLupien12,13,14,TrevorJ.Pugh12,13,MichaelD.Taylor1,2,11,15,18,MartinHirst9,10,ConnieJ.Eaves7,8,BenjaminD.Simons4,5,6,*,andPeterB.Dirks1,2,3,15,18,*1DevelopmentalandStemCellBiologyProgram,TheHospitalforSickChildren,Toronto,OntarioM5G0A4,Canada2TheArthurandSoniaLabattBrainTumourResearchCentre,TheHospitalforSickChildren,Toronto,OntarioM5G0A4,Canada3DepartmentofMolecularGenetics,UniversityofToronto,Toronto,OntarioM5S1A8,Canada4CavendishLaboratory,DepartmentofPhysics,J.J.ThomsonAvenue,CambridgeCB30HE,UnitedKingdomUsersmayview,print,copy,anddownloadtextanddata-minethecontentinsuchdocuments,forthepurposesofacademicresearch,subjectalwaystothefullConditionsofuse:http://www.nature.com/authors/editorial_policies/license.html#terms*CorrespondenceandrequestsformaterialsshouldbeaddressedtoP.B.D.(peter.dirks@sickkids.ca)andB.D.S.(bds10@cam.ac.uk).AuthorContributionsX.L.andP.B.D.conceptualizedthestudyandwereassistedbyL.V.N.,R.J.V.,N.I.P.,F.J.C.,H.J.S.,M.G.,andC.J.E.inexperimentaldesign.P.B.D.andB.D.S.supervisedthestudy.X.L.performedinvivoandinvitrobarcodingexperimentsanddrugvalidationstudies.D.J.J.,B.D.S.,X.L.,D.P.,A.C.,andP.B.D.analysedandinterpretedbarcodingresults.D.J.J.andB.D.S.developedthetheoreticalmodeloftumourgrowth,performedsimulationsandwrotethesupplementaltheorysection.F.M.G.C.,L.M.R.,M.D.T.,andT.J.P.analysedWESandRNA-seqresults.P.G.andM.L.performedATAC-seqandanalysedresults.R....
