Inflammasome-drivencatecholaminecatabolisminmacrophagesbluntslipolysisintheagedChristinaD.Camell1,2,JilSander6,OlgaSpadaro1,2,AileenLee1,2,KimY.Nguyen1,2,AllisonWing3,EmilyL.Goldberg1,2,Yun-HeeYoum1,2,ChesterW.Brown5,JohnElsworth4,MatthewS.Rodeheffer1,JoachimL.Schultze6,7,andVishwaDeepDixit1,2,8,91DepartmentofComparativeMedicine,YaleSchoolofMedicine,NewHaven,CT06520,USA2DepartmentofImmunobiology,YaleSchoolofMedicine,NewHaven,CT06520,USA3DepartmentofMolecular,CellularandDevelopmentalBiology,YaleSchoolofMedicine,NewHaven,CT06520,USA4DepartmentofPsychiatry,YaleSchoolofMedicine,NewHaven,CT06520,USA5GeneticsDivision,DepartmentofPediatrics,UniversityofTennesseeHealthScienceCenter,Memphis,TN381636GenomicsandImmunoregulation,LIMES-Institute,UniversityofBonn,53115,Bonn,Germany7SingleCellGenomicsandEpigenomicsUnitattheUniversityofBonnandtheGermanCenterforNeurodegenerativeDiseases,Bonn,Germany8YaleCenterforResearchonAging,YaleSchoolofMedicine,NewHaven,CT06520,USAAbstractCatecholamine-inducedlipolysis,thefirststepingenerationofenergysubstratesthroughhydrolysisoftriglycerides(TGs)1,declineswithage2,3.Thedefectinmobilizationoffreefattyacids(FFA)inelderlyisaccompaniedwithincreasedvisceraladiposity,lowerexercisecapacity,failuretomaintaincorebodytemperatureduringcoldstress,andreducedabilitytosurvivestarvation.Whilecatecholaminesignalinginadipocytesisnormalinelderly,howlipolysisisUsersmayview,print,copy,anddownloadtextanddata-minethecontentinsuchdocuments,forthepurposesofacademicresearch,subjectalwaystothefullConditionsofuse:http://www.nature.com/authors/editorial_policies/license.html#termsReprintsandpermissionsinformationisavailableatwww.nature.com/reprints9AddressandCorrespondenceto:VishwaDeepDixit,Ph.D.,SectionofComparativeMedicineandDepartmentofImmunobiology,YaleSchoolofMedicine,310CedarSt,NewHavenCT06520,Vishwa.Dixit@yale.edu,Phone:203-785-2525,Fax:203-785-7499.Theauthorsdeclarenocompetingfinancialinterests.DataAvailabilityStatement:SequencingdataisavailableattheGeneExpressi...
