11.Takentogether,ourdataprovidenewmechanisticinsightsintopossibleendogenoussignalingmetastaticsignalingpathwaysinvolvedinmaintainingproliferationandmigrationofbreastcancercells.2.Wesoughttodeterminewhetherseliciclib(CYC202,R‐roscovitine)couldincreasetheantitumoreffectsofdoxorubicin,withnoincreaseintoxicity,inanMCF7breastcancerxenograftmodel.3.MIB1(ki67)immunohistochemistrydemonstratedreducedproliferationwithtreatment.4.Survivinembodiestheseproperties,and5.Moreover,inpre‐clinicalbladdertumormodels,inhibitionofSurvivinexpressionand/orfunctionhasbeenshowntoimpedetumorcellproliferation,andmarkedlyinducespontaneousorchemotherapyinducedapoptosis6.Theefficacyofmainstaycancertherapies,cytotoxicsandradiation,hasreachedaplateauinthetreatmentofmanycancers,andthereisanurgentsensethatimprovementsmustnowcomefromfreshapproaches.7.Medianagewas62yearswitharangeof40‐74years.8.splicevariantsmightfunctionineffectasdominantnegativessothattheirexpressionmightconcurrentwithsurvivin.9.ThereisahypothesisthatXXX10.TheabsenceofinvivodataonthispointhasnowbeenremediedwithapaperinthisissueoftheJCIbyAltieriandcolleagues.11.Thus,thisraisesaninterestingquestionwhether...12.raisingthepossibilitythatmost,ifnotall,tumorsexpress...13.Thelevelsofp21andp27increasedaftertreatmentwithdoxorubicinorseliciclibaloneorincombination,comparedtountreatedcontrols.14.Incontrast,itisabundantlyexpressedinawidevarietyofmalignanttissues.15.Onthecontrary,...216.Bycontrast,agoodtitlewillattracttherelevantresearchersandincreasethenumberofcitationsyoureceive17.WehavefoundthatthehumanbreastcancercellsMCF‐7/AdroverexpressnotonlyP‐gpbutalsoXIAPandSurvivin,andshowedhighresistancetochemotherapeuticdrugsdoxorubicin,docetaxelandvincristine,incontrasttotheirparentalcellsKBandMCF‐7.18.Survivinisaberrantlyexpressedinvariouskindsofcancercellsbutisundetectableinnormaldifferentiatedadulttissues,withtheexceptionoftestis,thymus,andplacenta.19.TheattributablemortalityofCVCrelatedbloodstreaminfectionsrangesfrom0%to11.5%,20.Giventhe...
