·1266·第53卷第11期2023年11月Vol.53No.11Nov.2023日用化学工业（中英文）ChinaSurfactantDetergent&CosmeticsPreparationofpoly（lactic-co-glycolicacid）microsphereanditsbehaviorsofencapsulationandreleaseoftriamcinoloneacetonideWenboYuan1,HuatongZhang2,CongdeQiao2,LingWang2,MingmingLuan2,XiaodengYang2,*（1.EngineeringTechnologyCenter,ShandongGuyuchunBiotechnologyCo.,Ltd.,Jinan,Shandong250098,China;2.ShandongKeyLaboratoryofMolecularEngineering,QiluUniversityofTechnology,ShandongAcademyofSciences,Jinan,Shandong250353,China）Abstract:Triamcinoloneacetonidehastheadvantagesofstrongmedicalefficacyandlongduration,however,itsoilsolubilitylimitsitsapplication.Poly（lactic-co-glycolicacid）（PLGA）hasexcellentbiocompatibilityandbiodegradability,whichcanbemadeintomicrospheresloadedwithtriamcinoloneacetonide.Inthiswork,thePLGAwaspreparedusingtrifluoromethanesulfonicacidascatalystandglucoseasinitiator.Themolecularstructure,molecularweightandmolecularweightdistributionofPLGAwerecharacterizedbyNMRandgelchromatography.TheresultsshowedthatthemassratiooflacticacidtoglycolicacidsegmentsinPLGAwas50∶50,andthemoleculeswereterminatedwithcarboxylgroups,andthemolecularweightwasbetween36000and41000,exhibitingnarrowmolecularweightdistribution（molecularweightdistributionindexwasca.1.60）.Themicrospheresweremadebyelectrostaticsprayingmethod,whoseparticlesizewaslessthan20μm（thecontentofmicrospheresofdiameterbeingsmallerthan20μmwasmorethan92%）.Thedrugloadingefficiencyfortriamcinoloneacetonidewasmorethan44%,andtheperiodofreleasewasupto120h.Intheinitialstageofdrugrelease,therelationshipbetweendrugreleaserateandtimewaslinear.ThisworkcouldprovidebasicdataforthepreparationofPLGAmicrospheresfordrug-loadingandexpandtheapplicationoftriamcinoloneacetonideinthetreatmentofallergicdermatitis,neurodermatitisandchroniceczema.Moreover,thisworkcouldprovidereferenceforthedevelopmentoffunctionalskincareproducts.Keywords:triamcinoloneacetonide;poly（lactic-co-glycolicacid）;microsphere;drugloadingReceived:Octob...
