医药前沿2024年3月第14卷第9期综述·53·脓毒症诱导凝血障碍和弥散性血管内凝血的治疗进展赵森林，姜海明（通信作者）（滨州医学院烟台附属医院重症医学科山东烟台246199）【摘要】凝血障碍通常发生在脓毒症时，是宿主对感染的反应，可发展为弥散性血管内凝血（DIC），增加病死率。最近的研究进一步确定了导致血栓炎症反应和血管内血栓形成的因素。诊断DIC有助于脓毒症的管理，并与改善预后相关。尽管国际血栓和止血学会（ISTH）提出了诊断显性DIC的标准，但这些标准不适用于早期检测。因此，ISTHDIC科学标准化委员会提出了一个新的类别，称为“脓毒症诱导的凝血病（SIC）”，以促进DIC的早期诊断和对这些危重患者更快速的干预。SIC的治疗包括潜在感染的治疗和凝血病的纠正，大多数治疗方法集中于抗凝治疗。本文就脓毒症诱导凝血障碍和弥散性血管内凝血的治疗进展综述。【关键词】综述；脓毒症；弥散性血管内凝血；抗凝血酶；血栓调节素【中图分类号】R543【文献标识码】A【文章编号】2095-1752（2024）09-0053-04ProgressinthetreatmentofsepsisinducedcoagulationdisordersanddisseminatedintravascularcoagulationZHAOSenlin,JIANGHaiming(Correspondingauthor)DepartmentofCriticalCareMedicine,yantaiAffiliatedHospitalofbinzhouMedicalUniversity,yantai,Shandong246199,China【Abstract】Coagulationdisorderscommonlyoccurinsepsis,asahostresponsetoinfection,andcandevelopintodisseminatedintravascularcoagulation(DIC),increasingmortalityrates.Recentresearchhasfurtheridentifiedfactorscontributingtothromboinflammatoryresponsesandintravascularthrombusformation.DiagnosisofDICaidsinthemanagementofsepsisandisassociatedwithimprovedprognosis.AlthoughtheInternationalSocietyonThrombosisandHaemostasis(ISTH)hasproposedcriteriafordiagnosingovertDIC,thesestandardsarenotsuitableforearlydetection.Therefore,theISTHDICScientificStandardizationCommitteehasintroducedanewcategorytermed“sepsis-inducedcoagulopathy(SIC)”tofacilitateearlydiagnosisofDICandexpediteinterventionforcriticallyillpatients.TreatmentforSICinvolvesaddressingunderlyinginfectionsandcorrectingcoagulopathy,withmosttherapeuticapproachesfocusingonanticoagulationtherapy.Thisreviewsummarizesrecentadvancesinthetreatmen...
