StatisticsforBiologyandHealthSeriesEditorsK.Dietz,M.Gail,K.Krickeberg,J.Samet,A.TsiatisLemuelA.Moye´MultipleAnalysesinClinicalTrialsFundamentalsforInvestigatorsWith33IllustrationsLemuelA.Moye´DepartmentofBiostatisticsUniversityofTexasSchoolofPublicHealthHouston,TX77030USAmoyelaptop@msn.comSeriesEditorsK.DietzM.GailK.KrickebergInstitutfu¨rMedizinischeBiometrieNationalCancerInstituteLeChateletUniversita¨tTu¨bingenRockville,MD20892F-63270ManglieuWestbahnhofstrasse55USAFranceD-72070Tu¨bingenGermanyJ.SametA.TsiatisDepartmentofEpidemiologyDepartmentofStatisticsSchoolofPublicHealthNorthCarolinaStateUniversityJohnsHopkinsUniversityRaleigh,NC27695615WolfeStreetUSABaltimore,MD21205-2103USALibraryofCongressCataloging-in-PublicationDataMoye´,LemuelA.Multipleanalysesinclinicaltrials:fundamentalsforinvestigators/LemuelA.Moye´.p.cm.—(Statisticsforbiologyandhealth)Includesbibliographicalreferencesandindex.ISBN0-387-00727-X(hc.:alk.paper)1.Clinicaltrials.2.Multivariateanalysis.3.Clinicaltrials—Statisticalmethods.I.Title.II.Series.R853.C55M692003610′.7′27—dc212003044598ISBN0-387-00727-XPrintedonacid-freepaper.©2003Springer-VerlagNewYork,Inc.Allrightsreserved.Thisworkmaynotbetranslatedorcopiedinwholeorinpartwithoutthewrittenpermissionofthepublisher(Springer-VerlagNewYork,Inc.,175FifthAvenue,NewYork,NY10010,USA),exceptforbriefexcerptsinconnectionwithreviewsorscholarlyanalysis.Useinconnectionwithanyformofinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdevelopedisforbidden.Theuseinthispublicationoftradenames,trademarks,servicemarks,andsimilarterms,eveniftheyarenotidentifiedassuch,isnottobetakenasanexpressionofopinionastowhetherornottheyaresubjecttoproprietaryrights.PrintedintheUnitedStatesofAmerica.987654321SPIN10918937www.springer-ny.comSpringer-VerlagNewYorkBerlinHeidelbergAmemberofBertelsmannSpringerScience+BusinessMediaGmbHToDixieandtheDELTsviiPrefacePrefacesarenotforthosewhoareinarush.Ifyoucan...
