中国组织工程研究第16卷第31期2012–07–29出版ChineseJournalofTissueEngineeringResearchJuly29,2012Vol.16,No.31猪劈离式原位肝移植动物模型建立及麻醉处理★孙建军，陈国勇，汤高枫，陈建斌，王谦，谢占涛，赵会博，季节EstablishmentofaporcinesplittingorthotopiclivertransplantationmodelandmanagementofanesthesiaSunJian-jun,ChenGuo-yong,TangGao-feng,ChenJian-bin,WangQian,XieZhan-tao,ZhaoHui-bo,JiJie文章亮点：猪同种异体原位劈离式肝脏移植模型(沿Taira线)是大动物肝移植系列研究的较理想动物模型，在麻醉处理中，维持全肝阻断与开放前后血流动力学稳定，纠正与维持酸碱平衡及电解质紊乱，是手术成功的两大关键，另外，术中维持适当的体温亦是提高受体成活率，减少移植后并发症的重要方面。AbstractPeople’sHospitalofZhengzhou,Zhengzhou450003,HenanProvince,ChinaSunJian-jun★,Master,Associatechiefphysician,People’sHospitalofZhengzhou,Zhengzhou450003,HenanProvince,Chinasunjjandy@sohu.comdoi:10.3969/j.issn.2095-4344.2012.31.003Received:2012-04-21Accepted:2012-06-08郑州人民医院，河南省郑州市450003孙建军★，男，1972年生，河南省郑州市人，汉族，2005年郑州大学毕业，硕士，副主任医师，主要从事肝胆疾病的外科治疗及肝移植的研究。sunjjandy@sohu.com中图分类号:R617文献标识码:A文章编号:2095-4344(2012)30-05711-04收稿日期：2012-04-21修回日期：2012-06-08(20110621004/M·C)BACKGROUND:Theporcinesplittingorthotopiclivertransplantationtechniqueischaracterizedashighincidenceofbiliarycomplicationandischemicnecrosisoftheleftmediallobe.Inordertofurtherresearchthesplittinglivertransplantation,asuitableanimalisneedtoestablishthetransplantationandanesthesiamodel.OBJECTIVE:Toinvestigatetheestablishmentofporcinesplittingorthotopiclivertransplantationmodelandthecharacteristicsofanesthesiamanagement.METHODS:Forty3-month-oldpigsweighing25-30kgwereselected,theveno-venousbypasswasperformedundergeneralanesthesia,andthenthedonorliverwassplitalongTairaline.Afterthesectionwastrimmed,theorthotopiclivertransplantationwasperformed.RESULTSANDCONCLUSION:Theliverfunctionrecoveredwell,andthesurvivalrateafteroneweekwas50%,theoperativetimeofrecipientwas...
