Immunobiology of DC(1).PPTVIP免费

Centralcontrolofimmunity:ImmunobiologyofdendriticcellsHistoryofDCStudy1868P.LangerhansDCswerefirstidentifiedinepidermis(Langerhanscells)1973RM.SteinmanThepresenceofDCinothertissueswas&ZA.Cohnidentified1980sK.InabaMurineDCswereexpandedsuccessfullyinvitro1990sC.Caux&HumanDCswereexpandedsuccessfullyJ.BanchereauinvitroDendriticcellsareprofessionalantigenpresentingcellsthatplayapivotalroleinthecontrolofimmunityHematopoieticstem/progenitorcellsLymphoidprogenitorsBonemarrowNKcellsAntigensBlymphocytesPlasmacellsHumoralimmunityThymusTlymphocytesThcellsCTLCellularimmunityDCsDendriticcellsLymphocyteandDCcirculationsModelofDCmigrationandeffectsoninnateandadaptiveimmunityFeaturesthatchangeduringDCmaturationMoleculesexpressedbydendriticcellsOriginanddifferentiationofdendriticcellsDifferentiationandmaturationofDCsfromitsprecursorDCPrecursor(DCpre)MatureDC(DCmat)ImmatureDC(DCimm)Cytokines,e.g.GM-CSF,IL-4Pathogenes,e.g.LPSCytokines,e.g.TNFGM-CSFTcells,e.g.CD40LIL-10Cytokines,eg.SCF,Flt3L,GM-CSF,TNFHPCs(-)InvitrogenerationofdifferenttypesofhumanDCdependingonthecytokinesusedMyeloidimmatureCD11c+DCversusplasmacytoidDC:summaryofthemajorcharacteristicsofthosetwocelltypeswithrespecttotheirphenotypeandfunction(Human)Inhumanblood,thereexisttwotypesofDCprecursors:CD11c+pre-DC1monocytesandCD11c-IL-3R+CD45RA+plasmacytoidcells-alsotermedaspre-DC2.TcellstimulatedwithmatureCD11c+DCsshowaTh1-skewedcytokineproductionprofile,whereasthestimulatedTcellswithplasmacytoidcellsshowaTh2-skewedcytokineproduction,sotheyaretermedDC1andDC2respectively.HumanDCsubsetsDCsareheterogeneousinpopulations,andatleastthreeDCsubpopulationshavebeenidentifiedinthemousespleen,namelyCD8CD4,CD8CD4andCD8CD4,respectively.Recently,aplasmacytoidDCprecursor(CD11cintGr-1+B220+)wasidentifiedinmouselymphoidtissuesandblood.MouseDCsubsetsMaininvitrodifferentiationpathwaysofdendriticcells(DCs)inmiceDevelopmentofDCfromhematopoieticstemcellsMultipotenthematopoieticstemcellMyeloidprecursorsLymphoidprecursorsMonocyt...