·药物研究·麦冬多糖对妊娠期糖尿病小鼠胰岛抵抗作用的影响廖靖，蔡东红(广东医学院第二临床学院妇产科学教研室，广东东莞523808)摘要:目的观察麦冬多糖(ophiopogon－polysaccharide)对妊娠期糖尿病小鼠胰岛素抵抗作用的影响。方法采用链脲佐菌素(STZ)复制妊娠期小鼠糖尿病模型。将造模成功小鼠随机分为麦冬多糖125mg·kg－1组、500mg·kg－1组、格列本脲组、模型组，每组各10只。另取10只正常妊娠小鼠，作为正常对照组。连续灌胃给药14d，分别于给药第0、7、14天测定小鼠空腹血糖，给药第14天测定小鼠血清胰岛素水平及C－反应蛋白含量。结果口服麦冬多糖各剂量组均可降低妊娠糖尿病小鼠的空腹血糖、血清胰岛素水平及C－反应蛋白(CRP)水平，与模型组比较，差异有显著性(P＜0．05)。结论麦冬多糖有改善妊娠期糖尿病小鼠胰岛素抵抗的作用，其机制可能与降低及C－反应蛋白(CRP)水平有关。关键词:麦冬多糖;妊娠期糖尿病;胰岛素抵抗中图分类号:R965文献标识码:A文章编号:1672－7738(2011)08－0435－03Effectsofophiopogon-polysaccharideoninsulinresistanceofgestationaldiabetesmellitusmiceLIAOJing，CAIDong-hong(DepartmentofObstetrics＆GynecologyintheSecondClinicalSchool，GuangdongMedicalCollege，Dongguan523808，China)Abstract:ObjectiveToinvestigatetheeffectsofophiopogon-polysaccharideoninsulinresistanceingestationaldiabeticmices．MethodsThemodelofgestationaldiabeticmiceswereestablishedwithstreptozotocin(STZ)byintraperitonealinjectionadministration．Modelmiceswererandomizedintoophiopogon-polysaccharide125mg·kg－1group，ophiopogon-polysaccharide500mg·kg－1group，glibenclamidegroupandmodelgroup(n=10)．Normalpregnancymices(n=10)wereservedasnormalcontrolgroup．Ophiopogon-polysaccharidewasgivenbyintragastricadministrationfor14days．Thefastingbloodglucoselevelsofmicesatthe0，7，14dayweredetectedrespectively．TheseruminsulinlevelandCRPlevelweredetectedatthe14day．ResultsThefastingbloodglucoselevel，seruminsulinlevelandCRPlevelweresignificantlydecreasedingestationaldiabeticmicestreatedbyophiopogon-polysaccharidecomparedwithmodelgroup(P＜0．05)．ConclusionOphiopogon-polysaccharidecouldimprovetheinsulinresistanceofmice．Themechanismmayberelatedtothedecrea...
