目录What，知乎大佬竟然在Nature上发文！..................................................................3Nature子刊综述：APOE家族与阿尔兹海默的相爱相杀......................................10APOE生理特性..............................................................................................12APOE与Aβ......................................................................................................13APOE与tau蛋白、α-突触核蛋白以及.................................................16TDP43蛋白性疾病........................................................................................16APOE的其他致病机制................................................................................16APOE靶向性的AD治疗............................................................................17药物研发面临的挑战....................................................................................19待研究方向.......................................................................................................20不会研究疾病？来点简单的临床SNP套路............................................................21基线特征.............................................................................................................22miRNA-499的rs3746444与AEG的关系........................................................23不同亚组中miRNA-499rs3746444A>G多态性与AEG的关系............24组会宝典：如何结构化分析一篇23分顶刊文章....................................................26验证circHIPK3的表达及再糖网中的表达差异..........................................27通过―正反实验‖验证表型................................................................................30机制部分，寻找circHIPK3上游驱动机制..................................................34寻找circHIPK3下游调控机制........................................................................35总结......................................................................................................................42厉害了，伟哥能帮助治疗...
