SrcFAKGrb2GRB2p130Cofilin14-3-3ζMicalGIT1/2NckWASPRasRacCrkCortactinTropomyosinsWAVEPI5KPAK1MEKKPI3KPKD1PI3KMEKKMEKPAK1MBSRhomDIAROCKROCKLIMKMLCKMLCKMLCCalcineurinArp2/3Arp2/3SSHCaMCINCofilinHsp90ADFCapZTmodmDIAFilaminFilaminProfilinGelsolinPIXPIXTIAM1Vavcdc42CaMVASPWASPEnaFascinGEFPAK1PLCγPKCαPLCβPKARhoGEFPI3KPI3KPI3KαPaxillinRTKPlexinASeveredFilamentsSema1aIntegrinReceptorCa2+Ca2+PIP3PIP2PIP3PIP3PIP2LamellipodiaActinPolymerizationFilopodiaBarbed-endCappersPointed-endCappersFilopodiaNADPHF-actinBundles/MeshworksNADPDegradationStressFibersLamellipodiaIP3G13GPCRGiGqGsRegulationofActinDynamicswww.cellsignal.com©2008–2010CellSignalingTechnology,Inc.RegulationofActinDynamics•createdSeptember2008•revisedNovember2010DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
