SuFuGli1/2/3SuFuGli1/2/3SuFuPKACK1GSK-3ββ−TrCPGli1/2/3Gli3-RGli1/2/3Gli1/2-ActGli1/2-ActCyclinD,CyclinE,MycGli1,Patched,HIPHhNHhNHhSknDispatchedER/GolgiHhSecretingCellPTCH1NucleusGli1/2notranscriptionoftargetgenesNucleusCytoplasmCytoplasmActiveRepressorSmoSmoProteasomePrimaryCiliumPrimaryCiliumOn-StateOff-StateCDO/BOC(Ihog/boi)ShhKCTD11β-ArrestinKif3ADhhIhhMammalianLigands:PTCH1CDO/BOC(Ihog/boi)MicrotubulesMicrotubulesGli3-RGαiCOS2/Kif7COS2/Kif7HhNHedgehogSignalingInVertebrateswww.cellsignal.com©2006–2011CellSignalingTechnology,Inc.HedgehogSignalingInVertebrates•createdJune2006•revisedSeptember2011DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
