FLIPHtrA2GAS2ROCK1AcinusDFF40TNF-R1TNF-R2DR3APO-3DR4/5Fas/CD95DAPK1TRADDTRADDCYLDRIPTRADDTRADDRAIDDRIPFasLAPO-3L/TWEAKAPO-2L/TRAILRIPCasp-8,-10ComplexIIbNecroptosis+zVADBcl-2Apaf-1CytocBIDtBIDASK1ASK1NIKIKKIκBNF-κBNF-κBXIAPSmacMKK7JNKLaminA/CActinα-FodrinDFF45PARPCasp-7Casp-6Casp-9Casp-3FADDFADDTRAF2c-IAP1/2TRAF2FADDTRAF2FADDDaxxububTNF-αTNF-αRIP1RIP3Bcl-2Casp-8,-10FLIPSCellShrinkageMembraneBlebbingDNAFragmentationChromatinCondensationDNARepairApoptosisPro-ApoptoticPro-SurvivalDeathReceptorSignalingwww.cellsignal.com©2002–2012CellSignalingTechnology,Inc.DeathReceptorSignaling•createdJanuary2002•revisedFebruary2012DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
