TRADDRIPInflammatoryCytokines,FasLPax6CHOPETS1HMGN1RARαMK2MK2TauPRAKMEKK1-4TAO1/2/3MK3MK3PRAKTAB1DLKStat1p53MaxMycElk-1MEF2ATF-2HistoneH3CREBNF-κBp65ATF1ER81MSK1/2p38MAPKp38MAPKHSP27TRAF2DaxxMKK4MLK2/3ASK1/2TAK1MKK3/6cPLA2MNK1/2eEF2KTGF-βGαoDNADamage,OxidativeStress,UVSB203580ApoptosisCytokine-inducedmRNAstabilityTNF-αbiosynthesisCytoplasmNucleusTranscriptionCytokineProduction,Apoptosis,etc.TranslationGPCR©2003–2010CellSignalingTechnology,Inc.p38MAPKSignalingPathways•createdJanuary2003•revisedOctober2011SignalingPathwaysActivatingp38MAPKwww.cellsignal.comDirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
