ubTRADDTRAF6TRAF6Pellinoβ-TrCPTAK1JNKubTAB1/2ubA20MyD88IL-1RIKKβIKKγ/NEMOIKKαIKKγ/NEMORIPTaxβ-TrCPGF-RsTRAF2/5TNFRRasCotAktPI3KPDK1ubTRAF3LTβR,CD40,BR3NIKTRAF2/6IKKαIKKαubRelBNF-κB2p100ubIKKαIKKαRelBNF-κB2p52RelBNF-κB2p52H3PARP1IKKαIKKαNAP1PCAFacIKKγ/NEMOATMSUMOSUMOIKKγ/NEMONAKHDACPIASγCBP/p300RSK1PKACCK2NF-κBp50/52p65/RelANF-κBp50/52p65/RelAGSK-3βMSK1IKKα/β/εPKCζRelA/cRelNF-κB1p50IκBα/β/εIκBαNF-κB2p52p65/RelAubp38CK2NF-κB1p50RelA/cRelIκBα/εNF-κBp50/52NF-κBp50/52Bcl-3CYLDububububububITCHTAX1BP1TAK1TAB2/3ELKSubc5IκBζIRAK1/4Ubc13UEV1AProteasomalDegradationSurvival,Proliferation,Inflammation,ImmuneRegulationLymphogenesis,BCellMaturationProteasomalProcessingGenotoxicStressStress:ROIs,UV,metals,ischemia,shearK48-ubiquitinK63-ubiquitinubIL-1LT,CD40L,BAFF/BLysGrowthFactors:BMP,EGF,HGH,Insulin,NGF,TGF-αTNFUVNucleusCytoplasmubNuclear-cytoplasmicshuttlingofnon-phosphorylatedformsFordetailedsignaling,seeBCRPathway.BCRAgTCRAg-MHCFordetailedsignaling,seeTCRPathway.TLRsLPS,CpG,ssRNA,dsRNAFordetailedsignaling,seeTLRPathway.CYLDNF-κBSignalingwww.cellsignal.com©2003–2011CellSignalingTechnology,Inc.NF-κBSignaling•createdJanuary2003•revisedAugust2011DirectStimulatoryModificationKinasePhosphataseCaspaseReceptorCyclin,pro-apoptoticEnzymepro-survivalGAP/GEFGTPaseG-protein,ribosomalsubunitTranscriptionFactorTranscriptionalStimulationTranscriptionalInhibitionTranslocationSeparationofSubunitsorCleavageProductsJoiningofSubunitsDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationSignalingPathwaysKeywww.cellsignal.com©2003-2010CellSignalingTechnology,Inc.AcetylaseDeacetylase
