APFElevationMyocardialInfarctionUn-(临床研究）·论著··1209.临床医学工程12023年9月第30卷第9期冠状动脉内注射尿激酶原在ST段抬高型心肌梗死患者经皮冠状动脉介入术中的应用吴明明，刘冬梅，黄琳玲，罗培，房建斌，张巍（江苏省南通市如东县人民医院心血管内科，江苏南通226400）【摘要】目的探讨冠状动脉内注射尿激酶原在ST段抬高型心肌梗死（STEMI）患者经皮冠状动脉介入术（PCI）中的应用效果。方法将我院收治的84例STEMI患者随机分为两组各42例。对照组行常规PCI治疗，观察组PCI中于冠状动脉内注射尿激酶原。比较两组的临床疗效、TIMI血流分级和心肌损伤标志物变化。结果观察组治疗总有效率为90.48%，高于对照组的71.43%（P<0.05)。治疗后，观察组TIMI血流分级优于对照组（P<0.05。治疗后，观察组血清CK-MB、cTnI、BNP水平低于对照组（P<0.05)。结论冠状动脉内注射尿激酶原在STEMI患者PCI术中的应用效果确切，可明显提升临床疗效，有效改善患者的心肌血流灌注，减轻其心肌损伤。【关键词】ST段抬高型心肌梗死；PCI；尿激酶原；临床疗效；心肌损伤中图分类号：R542.2+2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.09.1209yInjectionofProurokinaseinPatientswithST-SegmentlicationofIntracoronaryInjectionofProurokinaseinPadergoingPercutaneousCoronaryIntervention//WUMingming,LIUDongmei,HUANGLinling,LUOPei,FANGJianbin,ZHANGWei(DepartmentofCardiovascularMedicine,RudongCountyPeople'sHospital,Nantong226400,China)[Abstract]ObjectiveToexploretheapplicationeffectofintracoronaryinjectionofprourokinaseinpatientswithST-segmentelevationmyocardialinfarction(STEMI)undergoingpercutaneouscoronaryintervention(PCI).Methods84STEMIpatientsadmittedtoourhospitalwererandomlydividedintotwogroups,with42casesineachgroup.ThecontrolgroupwastreatedwithroutinePCI,andtheobservationgroupwastreatedwithintracoronaryinjectionofurokinaseduringPCI.Theclinicalefficacy,TIMIbloodflowgradingandchangesofmyocardialinjurymarkerswerecomparedbetweenthetwogroups.ResultsThetotaleffectiverateoftreatmentintheobservationgroupwas90.48%,higherthan71.43%inthecontrolgroup(P<0.05).Aftertreatment,theTIMIbloodflowgradingoftheobservationgroupwasbetterthanthatofthecontrolgroup(P<0.05).Aftertreatment,...
