述1362Publishedonlinewww.wanfangdata.com.cndoi:10.3969/j.issn.1006-7108.2023.09.019ChinJOsteopeptember2023.Vol29,No.9oro中国骨质疏松杂志2023年9月第29卷第9期骨质疏松症中lncRNA可调控的骨代谢相关因子余子维陈剑峰*邓乔松李冠莘张楠南京中医药大学无锡附属医院，江苏无锡214000中图分类号：R681文献标识码：A文章编号：1006-7108(2023)09-1362-05摘要：近年来骨质疏松症（osteoporosis,OP）的患病率在不断增加，已经逐渐成为中国的重大公共卫生问题。由骨质疏松症引发的椎体骨折、髋部骨折、腕部骨折等导致的慢性疼痛、活动受限、长期卧床、身体畸形，已严重影响患者的生活质量。本文意在通过总结长链非编码RNA（longnon-codingRNA,lncRNA）调控的骨代谢相关因子对骨质疏松症的影响，为骨质疏松症的诊治和预防提供一种新的思路。已有一部分的研究证明lncRNA能够通过各种信号通路参与骨代谢，但目前关于lncRNA可调控的相关因子的研究还不够全面，其具体的作用机制、功能还有待进一步探索，将其作为靶向治疗应用于临床也具有很大的挑战。关键词：骨质疏松症；长链非编码RNA；骨代谢Bonemetabolism-relatedfactorsregulatedbylncRNAinosteoporosisYUZiwei,CHENJianfeng",DENGQiaosong,LIGuanshen,ZHANGNanWuxiChineseMedicineHospital,NanjingUniversityOfChineseMedicine,Wuxi214000,China*Correspondingauthor:CHENJianfeng,Email:wxzy009@njucm.edu.cnAbstract:Theprevalenceofosteoporosis(OP)hasbeencontinuouslyincreasinginrecentyearsandhasgraduallybecomeamajorpublichealthprobleminChina.Chronicpain,limitedmobility,prolongedbedrestandphysicaldeformitycausedbyvertebralfractures,hipfracturesandwristfracturescausedbyosteoporosishaveseriouslyaffectedthequalityoflifeofpatients.Thispaperintendstoprovideanewideaforthediagnosis,treatmentandpreventionofosteoporosisbysummarizingtheeffectsoflongnon-codingRNA(IncRNA)-regulatedbonemetabolism-relatedfactorsonosteoporosis.SomestudieshavedemonstratedthatlncRNAscanparticipateinbonemetabolismthroughvarioussignalingpathways,butthecurrentresearchonlncRNA-regulatedfactorsisnotcomprehensiveenough,andtheirspecificmechanismsofactionandfunctionsneedtobefurtherexplored,andtheirapplicationastargetedtherapiesinclinicalsettingsisalsochalleng...
