Bioprocess生物过程,2023,13(3),142-146PublishedOnlineSeptember2023inHans.https://www.hanspub.org/journal/bphttps://doi.org/10.12677/bp.2023.133020文章引用:冯吉,郭伟.骨钙素与葡萄糖代谢、能量代谢的研究进展[J].生物过程,2023,13(3):142-146.DOI:10.12677/bp.2023.133020骨钙素与葡萄糖代谢、能量代谢的研究进展冯吉1,郭伟2*1西安医学院研究生院,陕西西安2陕西省人民医院,全科医学科,陕西西安收稿日期:2023年6月28日;录用日期:2023年8月28日;发布日期:2023年9月7日摘要骨钙素(OCN)是一种源自成骨细胞的非胶原蛋白,具有多种激素特征。动物和实验模型表明,骨钙素被释放到血液中,能够对胰腺细胞和脂肪组织产生生物学效应。近些年来,研究者们开始把骨骼作为一个内分泌器官重视起来,发现未完全羧化的骨钙素(ucOC)具有一定的活性,能够在葡萄糖代谢及能量代谢中发挥不可或缺的作用,这使得骨钙素可能在代谢性疾病,如糖尿病、肥胖和代谢综合征中具有潜在的治疗意义。关键词骨钙素,葡萄糖代谢,能量代谢AdvancesintheStudyofOsteocalcin,GlucoseMetabolismandEnergyMetabolismJiFeng1,WeiGuo2*1GraduateSchoolofXi’anMedicalCollege,Xi’anShaanxi2DepartmentofGeneralPractice,ShaanxiProvincialPeople’sHospital,Xi’anShaanxiReceived:Jun.28th,2023;accepted:Aug.28th,2023;published:Sep.7th,2023AbstractOsteocalcin(OCN)isanon-collagenousproteinderivedfromosteoblastswithavarietyofhor-monalcharacteristics.Animalandexperimentalmodelshaveshownthatosteocalcinisreleasedintothebloodstreamandiscapableofproducingbiologicaleffectsonpancreaticcellsandadiposetissue.Inrecentyears,researchershavebeguntofocusontheskeletonasanendocrineorgan,and*通讯作者。冯吉,郭伟DOI:10.12677/bp.2023.133020143生物过程havefoundthatundercarboxylatedosteocalcin(ucOC)isactiveandabletoplayanintegralroleinglucosemetabolismandenergymetabolism,whichmakesitpotentiallytherapeuticinmetabolicdisorderssuchasdiabetesmellitus,obesity,andmetabolicsyndrome.KeywordsOsteocalcin,GlucoseMetabolism,EnergyMetabolismCopyright©2023byauthor(s)andHansPublishersInc.ThisworkislicensedundertheCreativeCommonsAttributionInternationalLicense(CCBY4.0).http://creativecommons.org/licenses/by/4.0/1.骨钙素...