专家论坛Jun.2023,Vol.37,No.6ChinDermatovenereol2023年6月中国皮肤性病学杂志第37卷第6期关节病型银屑病动物模型的发展现状晏少琛"，史琳丽"，戴生明²，毕新岭[摘商要关节病型银屑病（psoriasisarthropathica）又称银屑病关节炎（psoriaticarthritis,PsA），是银屑病的一种特殊类型，常见表现为外周关节炎、指（趾）炎、附着点炎和脊柱炎。PsA的动物模型研究目前取得一定进展，但能够比较全面表现皮肤和关节病变的可靠动物模型尚未被开发出来。该文按自发性动物模型、基因工程动物模型、诱导性动物模型、类风湿关节炎相关模型以及脊柱关节炎相关模型进行归类，对近年国内外模拟人类PsA特征的动物模型进行了阐述，为开展PsA相关工作的科研人员提供参考。[关键词]银屑病；关节病型；动物模型[中图分类号]R758.63[文献标志码]A[文章编号]1001-7089(2023)06-0611-06[DOI]10.13735/j.cjdv.1001-7089.202203084DevelopmentandCurrentSituationofAnimalModelsofPsoriasisArthropathicaYANShaochen',SHILinli',DAIShengming’,BIXinling'(1.DepartmentofDermatology,theFirstAffiliatedHospitalofNavalMedicalUniversity,Shanghai200433,China;2.DepartmentofRheumatologyandImmunology,theSixthPeople'sHospitalAfilia-tedtoShanghaiJiaotongUniversity,Shanghai200233,China)[CorrespondingauthorBIXinling,E-mail:bixinling@163.com[Abstract]Psoriasisarthopathica,alsoknownaspsoriaticarthritis(PsA),isaspecialsubtypeofpsoriasis.Thecommonmanifestationsareperipheralarthritis,dactylitis,enthesitisandspondylitis.Atpresent,someprogresshasbeenmadeinthestudyofanimalmodelsofPsA,butthereliableanimalmodelwhichcanfullymimiclesionsofskinandjointofPsAhasnotbeendeveloped.ThispapersummarizedtheanimalmodelsthatsimulatedthecharacteristicsofhumanPsAinrecentyearsaccordingtospontaneousanimalmodel,geneticallyengineeredmousemodel,inducibleanimalmodel,rheumatoidarthritis-relatedmodelandspondyloarthritis-relatedmodel,inordertoprovidereferenceforresearchersontheworkofPsA.[Keywords]Psoriasis;Arthropathica;Animalmodel关节病型银屑病（psoriasisarthropathica）又称银屑病关节炎（psoriaticarthritis,PsA）是银屑病的一种特殊类型，常见表现为外周关节炎、指（趾)炎、附着点炎和脊柱炎")。据研究，世界各个地区银屑...
