Author’sAcceptedManuscriptTheTumorSuppressorProteinp53andtheFerroptosisNetworkRuiKang,GuidoKroemer,DaolinTangPII:S0891-5849(18)30907-9DOI:https://doi.org/10.1016/j.freeradbiomed.2018.05.074Reference:FRB13776Toappearin:FreeRadicalBiologyandMedicineReceiveddate:5April2018Reviseddate:16May2018Accepteddate:19May2018Citethisarticleas:RuiKang,GuidoKroemerandDaolinTang,TheTumorSuppressorProteinp53andtheFerroptosisNetwork,FreeRadicalBiologyandMedicine,https://doi.org/10.1016/j.freeradbiomed.2018.05.074ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultinggalleyproofbeforeitispublishedinitsfinalcitableform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.www.elsevier.com1TheTumorSuppressorProteinp53andtheFerroptosisNetworkRuiKang1,2,GuidoKroemer3-9,andDaolinTang1,2*1TheThirdAffiliatedHospital,CentralofDAMPBiology,GuangzhouMedicalUniversity,Guangzhou,Guangdong510150,China2DepartmentofSurgery,UniversityofPittsburgh,Pittsburgh,Pennsylvania15213,USA3UniversitéParisDescartes,SorbonneParisCité;75006Paris,France4Equipe11labelliséeLigueNationalecontreleCancer,CentredeRecherchedesCordeliers;75006Paris,France5InstitutNationaldelaSantéetdelaRechercheMédicale,U1138;Paris,France6UniversitéPierreetMarieCurie,75006Paris,France7MetabolomicsandCellBiologyPlatforms,GustaveRoussyCancerCampus;94800Villejuif,France8PôledeBiologie,HôpitalEuropéenGeorgesPompidou,AP-HP;75015Paris,France9DepartmentofWomen'sandChildren'sHealth,KarolinskaUniversityHospital,17176Stockholm,Sweden*Addresscorrespondenceandreprintrequeststo:DaolinTang(tangd2@upmc.edu)AbstractFerroptosisisaformoflipidperoxidation-inducedcelldeaththatcanberegulatedinmanyways,fromalteringtheactivityofantioxidantenzymestotheleveloftranscriptionfactors.Thep53tumorsuppressoris'theguardianof...
