CellSignalingTechnology©2003–2016CellSignalingTechnology,Inc.www.cellsignal.comDirectStimulatoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTentativeInhibitoryModificationDirectInhibitoryModificationMultistepStimulatoryModificationMultistepInhibitoryModificationTentativeStimulatoryModificationTranscriptionalInhibitoryModificationKinasePhosphataseTranscriptionFactorCaspaseReceptorEnzymepro-apoptoticpro-survivalGAP/GEFGTPaseG-proteinAcetylaseDeacetylasePathwayDiagramKeyWnt/β-CateninSignalingWTXTAB1TAB2SFRPSFRPWIFPorcWLSWntDKKsR-spondinsFrizzledFrizzledAPCβ-TrCPGrouchoICATChibbyLEF1/TCF1DvlDvlNakedRNF43ZNRF3LGR5/6PAR-1LRP5/6AxinAxinPP2ATCF3Brg1PygoBCL9α-cateninp120LRP5/6GrouchoFoxOSnail1TAZFoxOSkpβ-cateninβ-cateninβ-cateninCYLDTankyraseHDACCBPβ-cateninNLKNLKRac1GSK-3GSK-3β-cateninTAK1ubCadherinCK1CK1ubβ-cateninHDACβ-cateninubOFFHesx1TargetGenes:Myc,CyclinD1,TCF-1,PPAR-δ,MMP-7,Axin-2,CD44,etc.ON-StateOFF-StateNucleusCytoplasmMigrationAdhesionProteasomalDegradationPit1
