TCellImmuneCheckpointsChimerigenLaboratoriesCMChimerigenLaboratoriesCMMAY2016www.adipogen.cominfo@adipogen.comRegulationandactivationofTlymphocytesdependonsignalingbytheTcellreceptor(TCR)andalsobycosignalingreceptorsthatdelivernegative(–)orpositive(+)signals.APC/Tumorcell/DendriticcellTcell?CD28PD-1[CD279]CTLA-4[CD152]++++––PD-L1[B7-H1;CD274]orPD-L2[B7-DC;CD273]CD80[B7-1]orCD86[B7-2]ICOS[CD278]+ICOSL[B7-H2;B7RP1;CD275]?–B7-H3[CD276]/B7-H4[VTCN1]?TMIGD2[IGPR-1]?––VISTA[B7-H5;PD-1H;Gi24]B7-H7[HHLA2]Cytokines(TGFβ,IL-1,IL-6,IL-10,IL-12,IL-18)|Tryptophan|–IDO1,TDO+–?ButyrophilinFamilyMembers(e.g.Btnl2,Skint1,MOG,CD277)BTLA[CD272]CD137[TNFRSF9;4-1BB]OX40[TNFRSF4;CD134]CD27[TNFRSF7]CD40L[TNFSF5;CD154]+++++++––––––GITR[TNFRSF18;CD357]CD96CD155[PVR;Necl-5]CD226[DNAM-1]TIGITCD112[PVRL2;Nectin-2]CD112RCD200R2B4[CD244]CD200CD48[BCM-1;BLAST-1]GITRL[TNFSF18]HVEM[TNFRSF14;CD270]CD137L[TNFSF9;4-1BBL]OX40L[TNFSF4;CD252]CD70[TNFSF7;CD27L]CD40[TNFRSF5]TIM-3[HAVcr-2]Gal-9–A2aRAdenosineKIRLKIRSTCRLAG-3[CD223]Peptide––SIGNALMHCclassIorIIREVIEWS:Immunecheckpointblockadeimmunotherapytoactivateanti-tumourT-cellimmunity:A.G.Ramsay;Br.J.Haematol.162,313(2013)·Immunecheckpointblockade:acommondenominatorapproachtocancertherapy:S.L.Topalian,etal.;CancerCell.27,450(2015)
