CB34CH12_MontellARI31July201813:45AnnualReviewofCellandDevelopmentalBiologyUnconventionalWaystoLiveandDie:CellDeathandSurvivalinDevelopment,Homeostasis,andDiseaseSwapnaA.Gudipaty,1ChristopherM.Conner,2JodyRosenblatt,1andDeniseJ.Montell21DepartmentofOncologicalSciencesandHuntsmanCancerInstitute,UniversityofUtah,SaltLakeCity,Utah84112,USA2Molecular,Cellular,andDevelopmentalBiologyDepartment,UniversityofCalifornia,SantaBarbara,California93106,USA;email:denise.montell@lifesci.ucsb.eduAnnu.Rev.CellDev.Biol.2018.34:12.1–12.22TheAnnualReviewofCellandDevelopmentalBiologyisonlineatcellbio.annualreviews.orghttps://doi.org/10.1146/annurev-cellbio-100616-060748Copyrightc⃝2018byAnnualReviews.AllrightsreservedKeywordsapoptosis,extrusion,anastasis,autophagy,necrosis,celldeathAbstractBalancingcelldeathandsurvivalisessentialfornormaldevelopmentandhomeostasisandforpreventingdiseases,especiallycancer.Conventionalcelldeathpathwaysincludeapoptosis,aformofprogrammedcelldeathcontrolledbyawell-definedbiochemicalpathway,andnecrosis,thelysisofacutelyinjuredcells.Newtypesofregulatedcelldeathincludenecropto-sis,pyroptosis,ferroptosis,phagoptosis,andentosis.Autophagycanpromotesurvivalorcancausedeath.Newlydescribedprocessesofanastasisandresus-citationshowthat,remarkably,cellscanrecoverfromthebrinkofapoptosisornecroptosis.Importantnewworkshowsthatepitheliaachievehomeosta-sisbyextrudingexcesscells,whichthendiebyanoikisduetolossofsurvivalsignals.Thismechanicallyregulatedprocessbothmaintainsbarrierfunctionascellsdieandmatchesratesofproliferationanddeath.Inthisreview,wedescribetheseunconventionalwaysinwhichcellshaveevolvedtodieorsur-vive,aswellasthecontributionsthattheseprocessesmaketohomeostasisandcancer.12.1ReviewinAdvancefirstpostedonAugust8,2018.(Changesmaystilloccurbeforefinalpublication.)Annu.Rev.CellDev.Biol.2018.34.Downloadedfromwww.annualreviews.orgAccessprovidedbyAustralianNationalUniversityon08/09/18.Forpersonaluseonly.CB34CH12_MontellARI31July201813:45ContentsINTRODUCTION...............
