BoneMarrowNicheTraffickingofmiR-126ControlsSelf-RenewalofLeukemiaStemCellsinChronicMyelogenousLeukemiaBinZhang1,10,12,LeXuanTruongNguyen1,2,10,LingLi1,DandanZhao1,BijenderKumar1,HermanWu1,AllenLin1,FrancescaPellicano3,LisaHopcroft3,Yu-LinSu4,MhairiCopland3,TessaL.Holyoake3,CalvinJ.Kuo5,RaviBhatia6,DavidS.Snyder1,HarisAli1,AnthonyS.Stein1,CaseyBrewer1,HuafengWang1,7,TinishaMcDonald1,PiotrSwiderski1,EstelleTroadec1,Ching-ChengChen1,AdrienneDorrance8,VinodPullarkat1,Yate-ChingYuan1,DaniloPerrotti9,NadiaCarlesso1,StephenJ.Forman1,MarcinKortylewski4,11,Ya-HueiKuo1,11,andGuidoMarcucci1,11,121GehrFamilyCenterforLeukemiaResearch,HematologyMalignanciesandStemCellTransplantationInstitute,CityofHopeMedicalCenter,DuarteCA2DepartmentofMedicalBiotechnology,BiotechnologyCenterofHoChiMinhCity,Vietnam3PaulO’GormanLeukemiaResearchCentre,CollegeofMedical,Veterinary&LifeSciences,InstituteofCancerSciences,UniversityofGlasgow,Scotland,UK4DepartmentofImmuno-Oncology;CityofHopeMedicalCenter,DuarteCA5StanfordUniversitySchoolofMedicine,Stanford,CA6UniversityofAlabamaatBirmingham,Birmingham,AL7DepartmentofHematology,theFirstAffiliatedHospital,ZhejiangUniversityschoolofmedicine,Hangzhou,Zhejiang,PRChina8OhioStateUniversity;ColumbusOH9UniversityofMaryland,Baltimore,MDAbstractChronicmyelogenousleukemia(CML)stemcells(LSCs)areresponsibleforinitiatingandmaintainingclonalhematopoiesis.Thesecellspersistinthebonemarrow(BM)despiteeffectiveUsersmayview,print,copy,anddownloadtextanddata-minethecontentinsuchdocuments,forthepurposesofacademicresearch,subjectalwaystothefullConditionsofuse:http://www.nature.com/authors/editorial_policies/license.html#terms12Correspondenceshouldbeaddressedto:BinZhangandGuidoMarcucci,CityofHopeMedicalCenter,1500EDuarteRoad,DuarteCA91010.Phone:626-256-4673;FAX:626-301-8973.bzhang@coh.orgorgmarcucci@coh.org.10Theseauthorscontributedequally11TheseseniorauthorscontributedequallyConflictofinterest:noneAuthorcontributionsBZandL.X.T.Ndesignedandconductedexperiments,analyzeddataan...
