EffectorProteinBacteriaBiochemicalFunctionCellularTargetPhenotypeSopE/SopE2SalmonellaentericaGuaninenucleotideexchangefactor(GEF)RhofamilyGTPasesStimulationofactinreorganizationandbacterialentryintononphagocyticcells;nuclearresponsesSptP(Nterminus)/YopE/ExoS(Nterminus)S.enterica/Yersiniaspp./PseudomonasaeruginosaGTPase-activatingprotein(GAP)Rho-familyGTPasesRecoveryoftheactincytoskeletonafterbacterialinternalization(SptP);disruptionoftheactincytoskeleton(YopE/ExoS)SipAS.entericaActinnucleatorActinStimulationofactincytoskeletonreorganizationandbacterialentryintononphagocyticcellsSopAS.entericaHECT-likeubiquitinligaseUnknownPromotesinflammationSopB/IpgBS.enterica/Shigellaspp.PhosphoinositideandinositolphosphatephosphatasePhosphoinositidesandinositolphosphatesStimulationofactincytoskeletonreorganizationandmacropinocytosis;bacterialinternalizationintononphagocyticcells;modulationofvesiculartraffickingSipCS.entericaActinbundlingActinModulationofactincytoskeletontopromotebacterialinternalizationintohostcellsSifAS.entericaRecruitsSKIPtotheSalmonella-containingvacuoleSKIPandkinesinModulationofvesiculartraffickingSseJS.entericaDeacylaseUnknownUnknownSseLS.entericaUbiquitinproteaseUbiquitinMacrophagekillingSrfHS.entericaUnknownTRIP6PromotesmotilityofinfectedcellsSspH1S.entericaUnknownPKN1Inhibitionofhostinflammatoryresponse?YopJ/AvrA/AvrBsT(andotherfamilymembers)Yersiniaspp./S.entericaAcetyltransferase/cysteineproteaseMAPKKandIKKfamilymembers;SUMO?DisruptionofMAPkinaseandNF-κBsignaling(YopJ);disruptionofplantdefenseresponses(AvrBsT)PipB2S.entericaRecruitmentofkinesinKinesinPhagosomemovementalongmicrotubules?YopT/HopC1(andotherfamilymembers)Yersiniaspp./PseudomonassyringaeProteaseRho-familyGTPases(YopT);PBS1kinase(AvrPphB)Disruptionoftheactincytoskeleton(YopT);modulatesthejasmonicaciddefenseresponseinplants(AvrPphB)YopH/SptP(Cterminus)Yersiniaspp./S.entericaProteintyrosinephosphataseManyDisruptionofmacrophagefunctions(YopH);disruptionofMAPkinasesignaling(SptP)YpkAYersinias...
