ResourceComparativeHeterochromatinProfilingRevealsConservedandUniqueEpigenomeSignaturesLinkedtoAdaptationandDevelopmentofMalariaParasitesGraphicalAbstractHighlightsdMulti-genefamiliesarecommontargetsofheterochromatininmalariaparasitesdConservedheterochromaticgenesarerareandtendtohaveregulatoryfunctiondHeterochromatinisstableduringasexualreplicationbutvariablebetweenstrainsdGametocytedifferentiationislinkedtochangesintheheterochromatinlandscapeAuthorsSabineA.Fraschka,MichaelFilarsky,ReginaHoo,...,PeterR.Preiser,Richa´rdBa´rtfai,TillS.VossCorrespondencer.bartfai@science.ru.nl(R.B.),till.voss@swisstph.ch(T.S.V.)InBriefFraschka,Filarskyetal.performedagenome-widecharacterizationofheterochromatinorganizationacrossmultiplespecies,strains,andlifecyclestagesofmalariaparasites.Thisrevealedthatheterochromaticgenesilencingisaconservedstrategytodriveclonalvariationofsurfaceantigensandtocontrollifecyclestagetransitionsandcelldifferentiation.Fraschkaetal.,2018,CellHost&Microbe23,407–420March14,2018ª2018TheAuthor(s).PublishedbyElsevierInc.https://doi.org/10.1016/j.chom.2018.01.008CellHost&MicrobeResourceComparativeHeterochromatinProfilingRevealsConservedandUniqueEpigenomeSignaturesLinkedtoAdaptationandDevelopmentofMalariaParasitesSabineA.Fraschka,1,11MichaelFilarsky,2,3,11ReginaHoo,4IgorNiederwieser,2,3XueYanYam,4NicolasM.B.Brancucci,5,6FranziskaMohring,7AnnalsT.Mushunje,4XimeiHuang,4PeterR.Christensen,8FrancoisNosten,8,9ZbynekBozdech,4BruceRussell,10RobertW.Moon,7MatthiasMarti,5,6PeterR.Preiser,4Richa´rdBa´rtfai,1,12,*andTillS.Voss2,3,12,13,*1DepartmentofMolecularBiology,FacultyofScience,RadboudUniversity,6525GANijmegen,theNetherlands2DepartmentofMedicalParasitologyandInfectionBiology,SwissTropicalandPublicHealthInstitute,4051Basel,Switzerland3UniversityofBasel,4001Basel,Switzerland4SchoolofBiologicalSciences,NanyangTechnologicalUniversity,Singapore637551,Singapore5InstituteofInfection,ImmunityandInflammation,UniversityofGlasgow,GlasgowG128QQ,UK6DepartmentofImmunologyandI...
