re论著儿科药学杂志2023年第29卷第8期JournalofPediatricPharmacy2023,Vol.29,No.813doi:10.13407/j.cnki.jpp.1672-108X.2023.08.0041例布洛芬混悬液致儿童重症多形红斑报道并布洛芬严重不良反应文献复习刘云媛，李娜，唐秀能（广西壮族自治区妇幼保健院，南宁530002)【摘要]目的：探讨布洛芬混悬液与重症多形红斑的相关性，为布洛芬的安全使用提供参考。方法：分析1例布洛芬混悬液导致重症多形红斑的病例，并进行文献复习。结果：根据国家药品不良反应中心药品不良反应/事件关联性评价标准，布洛芬混悬液引起重症多形红斑的可能性较大。查阅文献，布洛芬引起的皮肤不良反应大多为轻型药疹，罕见重型药疹，也有布洛芬引起多形红斑、Stevens-Johnson综合征、中毒性表皮坏死松解症、剥脱性皮炎、超敏反应综合征等严重皮肤不良反应的个例报道。结论：布洛芬临床应用广泛，耐受性好，但需警惕其严重皮肤不良反应。【关键词］布洛芬；多形红斑；重型药疹；不良反应[中图分类号]R969.3[文献标识码]A[文章编号]1672-108X(2023)08-0013-04ACaseofSevereErythemaMultiformeinChildrenInducedbyIbuprofenSuspensionandLiteratuReviewonSevereAdverseDrugReactionsInducedbyIbuprofenLiuYunyuan,LiNa,TangXiuneng(MaternalandChildHealthHospitalofGuangxiZhuangAutonomousRegion,Nanning530002,China)[AbstractjObjective:Toinvestigatethecorrelationbetweenibuprofensuspensionandsevereerythemamultiforme,soastoprovidereferenceforthesafeuseofibuprofen.Methods:Onecaseofsevereerythemamultiformeinducedbyibuprofensuspensionwasanalyzedandtheliteraturewasreviewed.Results:Accordingtoadversedrugreaction/eventcorrelationevaluationcriteriafromNationalCenterforAdverseDrugReactionMonitoring,severeerythemamultiformeinducedbyibuprofensuspensionhadhigherprobability.Afterliteraturereview,mostskinadversedrugreactionsinducedbyibuprofenweremilddrugeruptions,andseveredrugeruptionswererare.Therewerealsoindividualreportsofsevereskinadversedrugreactionsinducedbyibuprofen,suchaserythemamultiforme,Stevens-Johnsonsyndrome,toxicepidermolysisbullosa,exfoliativedermatitis,andhypersensitivitysyndrom.Conclusion:Ibuprofeniswidelyusedclinicallyandwelltolerated,yetcautionisneededforitssevereskinadversedrugreaction...
