·国家基金研究进展综述·施万细胞在恶性肿瘤进展中的作用*刘维帅王姗姗刘东颖摘要施万细胞（Schwanncells，SCs）是外周神经系统中最重要的神经胶质细胞类型，在神经损伤修复过程中起重要作用。近年来研究显示，SCs作为连接神经和肿瘤细胞的“桥梁分子”，通过与肿瘤细胞、免疫细胞、间质细胞等相互作用，改善局部肿瘤微环境，进而促使肿瘤嗜神经生长和神经支配、促进肿瘤的生长、迁移和侵袭，产生免疫抑制并出现肿瘤疼痛等一系列恶性生物学行为。本文就SCs在非神经肿瘤中的作用及其机制进行综述，以期为将来抗肿瘤治疗联合靶向SCs的治疗策略提供理论基础。关键词施万细胞肿瘤微环境周围神经侵犯神经重塑肿瘤疼痛doi:10.12354/j.issn.1000-8179.2023.20221209RoleofSchwanncellsintheprogressofmalignanttumorsWeishuaiLiu,ShanshanWang,DongyingLiuCorrespondenceto:DongyingLiu;E-mail:ldytjnk@sina.comDepartmentofPainManagement,TianjinMedicalUniversityCancerInstitute&Hospital,NationalClinicalResearchCenterforCancer,TianjinKeyLaboratoryofCancerPreventionandTherapy,Tianjin’sClinicalResearchCenterforCancer,Tianjin300060,ChinaThisworkwassupportedbytheNationalNaturalScienceFoundationofChina(No.82173118),theScience&TechnologyDevelop-mentFundofTianjinEducationCommissionforHigherEducation(No.2021KJ200)andTianjinKeyMedicalDiscipline(Specialty)Con-structionProject（No.TJYXZDXK-009A）AbstractSchwanncells(SCs)arethemostimportantglialcelltypeintheperipheralnervoussystemandplayanimportantroleinnervein-juryrepair.Inrecentyears,studieshaveshownthatSCsactasthebridgebetweennervesandtumorcells.Byconnectingwithtumor,im-mune,andmesenchymalcells,theyregulatethelocaltumormicroenvironment,enhanceperineuraltumorgrowthandinnervation,andpromotetumorgrowth,migration,andinvasion,producingimmunesuppressionandtumorpainandaseriesofmalignantbiologicalbehavi-or.ThisarticlereviewstheroleandmechanismofSCsinnon-neurologictumorstoprovideatheoreticalbasisforfuturetreatmentstrategiesofanti-tumortherapycombinedwithSCtargeting.Keywords:Schwanncells(SCs),tumormicroenvironment,peripheralnerveinvasion,nerveremodeling,cancerpain神经系统作为肿瘤微环境（tumormicroenviron-m...
