《食品工业》2023年第44卷第1期8工艺技术海参粉微丸制备工艺喻樊1,2,3,4*，蔡蓉1，蔡伶丽1,2,3,41.江苏省肿瘤靶向纳米诊疗材料工程研究中心，盐城师范学院（盐城224007）；2.药学院盐城师范学院（盐城224051）；3.江苏省滩涂生物资源与环境保护重点建设实验室（盐城224002）；4.南京工业大学（南京210000）摘要研究海参粉微丸的制备工艺。采用挤出滚圆法制备海参粉微丸;以圆整度为主要指标,采用单因素试验筛选最优制备工艺参数;考察微丸的粉体学性质;用红外光谱法、X射线衍射法、扫描电子显微镜法等方法对微丸进行表征。结果表明,挤出滚圆法最佳工艺参数为挤出频率30Hz、滚圆频率50Hz、滚圆时间4min。制备的海参粉微丸圆整度、流动性及堆密度均较好,且药物高度分散于微丸中。采用优化的工艺参数,利用挤出滚圆法制备海参粉微丸,简单易行,可用于生产。关键词海参粉;微丸;挤出滚圆法;粉体学性质;表征PreparationTechnologyofSeaCucumberPowderPelletsYUFan1,2,3,4*,CAIRong1,CAILingli1,2,3,41.JiangsuProvinceEngineeringResearchCenterofTumorTargetedNanoDiagnosticandTherapeuticMaterials,YanchengTeachersUniversity(Yancheng224007);2.CollegeofPharmacy,YanchengTeachersUniversity(Yancheng224051);3.JiangsuProvincialKeyLaboratoryofCoastalWetlandBioresourcesandEnvironmentalProtection(Yancheng224002);4.NanjingUniversityofTechnology(Nanjing210000)AbstractStudythepreparationtechnologyofseacucumberpowderpellets.Theseacucumberpowderpelletswerepreparedbyextrusionspheronizationmethod.Theoptimalpreparationparameterswereobtainedbysinglefactorexperiment.Micromeriticpropertiesweredetermined.Thepelletswerecharacterizedbyinfraredspectroscopy,X-raydiffractionandscanningelectronmicroscopy.Theoptimumtechnologyparameterswereasfollows:extrusionvelocityof30Hz,spheronizationvelocityof50Hz,andspheronizationtimeof4min.Theseacucumberpowderpelletspreparedbyextrusionspheronizationmethodwereallgoodofroundness,fluidityanddensity.Thedrugishighlydispersedinthepellets.Usingtheoptimizedparameters,thepreparationofseacucumberpowderpelletsbyextrusionspheronizationmethodissimpleandcanbeusedforproduction.Keywordsseacucumberpowder;pellets;extrusionspheronizationmethod;micromeriticsprope...
