肿瘤防治研究2023年第50卷第1期CancerResPrevTreat,2023,Vol.50,No.1·75·doi:10.3971/j.issn.1000-8578.2023.22.0642肝癌无创早期诊断的研究进展卢慧1，谢正元2ResearchProgressinNoninvasiveEarlyDiagnosisofHepatocellularCarcinomaLUHui1,XIEZhengyuan21.MedicalCollegeofNanchangUniversity,Nanchang330006,China;2.DepartmentofGastroenterology,TheSecondAffiliatedHospitalofNanchangUniversity,Nanchang330006,ChinaCorrespondingAuthor:XIEZhengyuan,E-mail:xzyxzy1230@163.comAbstract:Livercancerisacommontumorthatseriouslythreatenshumanlifeandhealth.Giventhattheearlyonsetoflivercancerisinsidiousandlacksspecificsymptoms,henceitisdifficulttoscreenthroughroutineexamination.Thus,clinicaldiagnosisoflivercancerismostlyintheadvancedstage.However,advancedlivercancerhasfewtreatmentoptions,poorprognosisandhighrelapserate,therebycausingahighmortalityrate.Therefore,earlydiagnosisoflivercancerisparticularlyimportant.Currently,non-invasivescreeningoflivercancerwidelyusedinclinicalsetupslackssufficientsensitivityandspecificity,hence,amorereliablediagnosticmethodneedstobefoundurgently.Thisarticlereviewstheresearchprogressofnoninvasiveearlydiagnosisoflivercancertoprovideareferenceforraisingtheearlydiagnosisrateoflivercancer.Keywords:Livercancer;Earlydiagnosis;Noninvasivediagnosis;Biomarkers;ImagingtechniquesFunding:NationalNaturalScienceFoundationofChina(No.81860119);KeyProjectofNaturalScienceFoundationofJiangxiProvince(No.20212ACB206017);KeyScienceandTechnologyR&DProjectofJiangxiProvince(No.20203BBG73044);ScienceandTechnologyResearchProjectofEducationDepartmentofJiangxiProvince(No.GJJ200193)Competinginterests:Theauthorsdeclarethattheyhavenocompetinginterests.摘要：肝癌是一种严重威胁人类生命健康的常见肿瘤，由于肝癌早期起病隐匿，缺乏特异症状，且常规检查难以筛查出早期肝癌，临床上肝癌的诊断多处于晚期。晚期肝癌可选择的治疗手段少、预后差、复发率高，导致肝癌病死率高，因此早期诊断尤为重要。目前广泛应用于临床的肝癌无创筛查缺少足够的灵敏度及特异度，迫切需要寻找更可靠的诊断方法。本文就肝癌无创早期诊断的研究进展进行...
