临床医学研究与实践2023年10月第8卷第29期摘要:目的分析兰索拉唑+奥曲肽+凝血酶治疗重症监护室(ICU)重症合并上消化道出血患者的有效性。方法选取2019年4月至2021年4月我院收治的82例ICU重症合并上消化道出血患者为研究对象,根据急诊顺序将其分为对照组(n=41,凝血酶)和研究组(n=41,兰索拉唑+奥曲肽+凝血酶)。比较两组的治疗效果。结果研究组的止血总有效率高于对照组,止血时间短于对照组,再出血率低于对照组,差异具有统计学意义(P约0.05)。治疗后,研究组的一氧化氮(NO)、丙二醛(MDA)、血管紧张素转化酶(ACE)、核因子-资B(NF-资B)水平低于对照组,差异具有统计学意义(P约0.05)。治疗后,研究组的胃泌素、胃蛋白酶原玉、胃蛋白酶原域水平低于对照组,差异具有统计学意义(P<0.05)。结论兰索拉唑+奥曲肽+凝血酶治疗ICU重症合并上消化道出血患者的止血效果理想,有助于改善预后。关键词:上消化道出血;重症监护室;兰索拉唑;奥曲肽;凝血酶中图分类号:R573.2文献标志码:A文章编号:2096-1413(2023)29-0049-04DOI:10.19347/j.cnki.2096-1413.202329013作者简介:吴炜(1990—),女,主治医师,硕士。研究方向:重症医学临床方面。Efficacyoflansoprazole+octreotide+thrombininthetreatmentofsevereICUpatientswithuppergastrointestinalbleedingWUWei,WANGWuhao,WANGJianhui(CriticalCareMedicineDepartment,LuoheCentralHospital/theFirstPeople'sHospitalofLuohe,Luohe462600,China)ABSTRACT:ObjectiveToanalyzetheefficacyoflansoprazole+octreotide+thrombininthetreatmentofsevereintensivecareunit(ICU)patientswithuppergastrointestinalbleeding.MethodsAtotalof82severeICUpatientswithuppergastrointestinalbleedingadmittedinourhospitalfromApril2019toApril2021wereselectedastheresearchobjects.Accordingtotheemergencyorder,thepatientsweredividedintocontrolgroup(n=41,thrombin)andstudygroup(n=41,lansoprazole+octreotide+thrombin).Thetherapeuticeffectsofthetwogroupswerecompared.ResultsThetotaleffectiverateofhemostasisinthestudygroupwashigherthanthatinthecontrolgroup,thehemostasistimewasshorterthanthatinthecontrolgroup,andtherebleedingratewaslowerthanthatinthecontrolgroup,thedifferenceswerestatisticallysignificant(P<0.05).Aftertreatment,thelevelsofnitricoxide(NO),...