中图分类号：R743.34文章编号：1006-351X（2023）10-0653-04文献识别码：A综述（收稿日期：2023-02-20）653脑与神经疾病杂志2023年第31卷第10期[40]MathewV,GershBJ,WilliamsBA,etal.Outcomesinpatientswithdiabetesmellitusundergoingpercutaneouscoronaryinterventioninthecurrentera:AreportfromthePreventionofREStenosiswithTranilastanditsOutcomes(PRESTO)trial[J].Circulation,2004,109:476-480.[41]YanL,LiuJ,ChenY,etal.TheRelationshipBetweenAPOEgenepolymorphismandin-stentrestenosisafterstentingatthebeginningofthevertebralartery[JJ.WorldNeurosurg,2022,158:e277-e282.[42]FanJ,WatanabeT.Atherosclerosis:Knownandunknown[J].PatholInt,2022,72(3):151-160.[43]IakovouI,SchmidtT,BonizzoniE,etal.Incidence,predictors,andoutcomeofthrombosisaftersuccessfulimplantationofdrug-elutingstents[JJ.JAMA,2005,293:2126-2130.[44]MaG,SongL,MaN,etal.Safetyandefficacyofrapamycin-elutingvertebralstentsinpatientswithsymptomaticextracranialvertebralarterySstenosis[J].FrontNeurol,2021,12:649426.Published2021Nov26.[45]MohammadRA,GoldbergT,DorschMP,etal.Antiplatelettherapyafterplacementofadrug-elutingstent:areviewofefficacyandsafetystudies[J]J.ClinTher,2010,32(14):2265-2281.[46]TopcuogluMA,ArsavaEM,AyH.Antiplateletresistanceinstroke[JJ.ExpertRevNeurother,2011,11(2):251-263.老年人眼底改变与脑小血管病的相关性贺沁飞贺一杰李泽杨柏楠吴云视网膜作为中枢神经的延续，其在解剖、功能、损伤反应以及免疫学方面表现出与神经系统相似的特征。如眼底有与血-脑脊液屏障（blood-cerebrospinalfluidbarrier，BCFB）结构相似的血－视网膜屏障（bloodretinalbarrier，BRB）。BCFB的损伤发生发展较为隐匿，检测手段局限，因而视网膜组织结构改变的敏感性以及其观察的简便性使其成为一个便利的研究工具。那通过视网膜结构改变的检测是否可以间接反应脑小血管病的情况呢？一、脑小血管病1.脑小血管病概述脑小血管病（cerebralsmallvesseldisease，CSVD）是一系列临床、影像学和病理综合征。CSVD有多种病因类型，临床表现也多样，大多数呈隐匿性起病。目前CSVD主要依靠神经影像学诊断。CSVD可呈现典型的影像学改变，但这些影像学表现只是脑小血管损伤的间接征象。2.CSVD流行特征目前血管性痴呆（vascularcogn...
