27上海医药2023年第44卷第17期（9月上）·药物临床·静吸复合麻醉和全凭静脉麻醉在老年髋关节置换术患者中的应用效果比较关清金菡李华平（中国人民解放军联勤保障部队第九八九医院平顶山医疗区麻醉科河南平顶山467000）摘要目的：比较静吸复合麻醉和全凭静脉麻醉在老年髋关节置换术患者中的应用效果。方法：将90例拟行髋关节置换术治疗的老年患者随机分为A组（n＝45，行静吸复合麻醉）和B组（n＝45，行全凭静脉麻醉）。比较两组心率（HR）、平均动脉压（MAP）、脑功能指标［神经元特异性烯醇化酶（NSE）、S100B蛋白和髓鞘碱性蛋白（MBP）］、免疫指标［白介素（IL）-2、IL-13、IL-4、干扰素-γ（IFN-γ）］水平。结果：A组切皮后30min（T2）时HR、MAP水平低于B组，术后24h时S100B蛋白、MBP、NSE、IL-13、IL-4水平低于B组，IL-2、IFN-γ水平高于B组（P＜0.05）。结论：静吸复合麻醉较全凭静脉麻醉可更有效地维持老年髋关节置换术患者围手术期血流动力学的稳定，减少术后免疫功能抑制与脑损伤。关键词老年髋关节置换术静吸复合麻醉全凭静脉麻醉中图分类号：R614;R687.42文献标志码：A文章编号：1006-1533(2023)17-0027-03引用本文关清,金菡,李华平.静吸复合麻醉和全凭静脉麻醉在老年髋关节置换术患者中的应用效果分析[J].上海医药,2023,44(17):27-29;65.ComparisonoftheeffectsofintravenousinhalationcombinedanesthesiaandtotalintravenousanesthesiainelderlyhiparthroplastypatientsGUANQing,JINHan,LIHuaping(DepartmentofAnesthesiology,PingdingshanMedicalDistrict,the989thHospitalofChinesePeople’sLiberationArmyJointLogisticSupportForce,Pingdingshan467000,China)ABSTRACTObjective:Tocomparetheeffectsofintravenousinhalationcombinedanesthesiaandtotalintravenousanesthesiainelderlypatientsundergoinghiparthroplasty.Methods:NinetycasesofelderlypatientsundergoinghiparthroplastywererandomlydividedintogroupA(treatedwithintravenousinhalationcombinedanesthesia)andgroupB(treatedwithtotalintravenousanesthesia)with45caseseach.Heartrate(HR),meanarterialpressure(MAP),brainfunctionindexes[neuron-specificenolase(NSE),S100Bprotein,andmyelinbasicprotein(MBP)],andimmuneindexes[interleukin(IL)-2,IL-13,IL-4,andinterferon-γ(IFN-γ)]levelswerecomparedbetweenthetwogroups.Results:ThelevelsofHRandMAPa...
