18·中国CT和MRI杂志2024年1月第22卷第1期总第171期【第一作者】王晓，女，主治医师，主要研究方向：神经系统MRI等影像学。E-mail：hy1564196@163.com【通讯作者】苏雪娟，女，主任医师，主要研究方向：核磁共振影像学研究等。E-mail：xueer1216@126.com论著StudyontheRelationshipbetweenCognitiveDysfunctionandHyperuricemiaandStructuralChangesofGrayMatterintheElderly*WANGXiao1,YANGMu2,YUWen-qing1,SUXue-juan1,*.1.DepartmentofRadiology,TheAffiliatedNanyangSecondGeneralHospital,XinxiangMedicalUniversity,Nanyang473012,HenanProvince,China2.DepartmentofNeurology,TheAffiliatedNanyangSecondGeneralHospital,XinxiangMedicalUniversity,Nanyang473012,HenanProvince,ChinaABSTRACTObjectiveToanalyzetherelationshipbetweencognitivedysfunctionandhyperuricemiaintheelderly,observethechangesinthebraingraymatterstructureofpatients,andexplorerelatedbrainmechanisms.MethodsProspectivelyselected392elderlypatientswithcognitivedysfunctionwhowerehospitalizedoroutpatientsinourhospital.Accordingtotheclassificationanddiagnosticcriteriaofcognitivedysfunctionandcognitiveassessmentscale,theyweredividedinto224casesofmildcognitiveimpairmentgroupand168casesofdementiagroup.Inaddition,182elderlypatientswhohadaphysicalexaminationinthishospitalduringthesameperiodwereselectedasthecontrolgroup.Comparetheblooduricacidlevelsofeachgroup,collectandanalyzepossibleinfluencingfactors.Usingvoxel-basedmorphometrytosegmentthepatient’stotalbrainvolume,runspm5inMatlab6.5toanalyzethecorrelationbetweenthegradingoftheMiniMentalStateChecklist(MMSE)andthetotalbraingraymattervolume.ResultsTheblooduricacidlevelofthedementiagroup[(419.47±32.51)μmol/L]wassignificantlyhigherthanthatofthemildcognitiveimpairmentgroup[(354.80±27.63)μmol/L]andthecontrolgroup[(226.48±32.15)μmol/L];theblooduricacidlevelofthemildcognitiveimpairmentgroupwassignificantlyhigherthanthatofthecontrolgroup(allP<0.01).Multivariatelogisticregressionanalysisshowedthatage(B=1.821,OR=2.134,95%CI=1.296~4.830,P=0.000),educationlevel(B=1.559,OR=1.607,95%CI=0.971~3.519,P=0.001),andhy...
