现代泌尿外科杂志·前列腺癌专题·酒精、咖啡、绿茶和乳制品的摄人量与前列腺癌的关联：两样本孟德尔随机化研究柴红强，邵晋凯，吴明，赵克洁，庞磊（山西医科大学第五临床医学院，山西省人民医院泌尿外科，山西太原030012）Associationsofalcohol,coffee,greenteaanddairyproductswithprostatecancer:atwo-sampleMendelianrandomizationstudyCHAIHongqiang,SHAOJinkai,WUMing,ZHAOKejie,PANGLei(DepartmentofUrology,TheFifthClinicalMedicalCollegeofShanxiMedicalUniversity,ShanxiProvincialPeople'sHospital,Taiyuan030012,China)ABSTRACT:ObjectiveAtwo-sampleMendelianrandomizationmethodwasusedtoexplorewhetherthereisacausalrelationshipbetweentheintakeofalcohol,coffee,greenteaanddairyproductsandtheincidenceofprostatecancer(PCa),inordertoclarifytheriskfactorsfortheincidenceofPCaandfindapreventionpathwayforPCa.MethodsDataofalcohol,coffee,greentea,dairyproductsandprostatecancerwerecollectedwithgenome-wideassociationstudy(GWAS).ThecausalrelationshipbetweentheirintakeandtheriskofPCawasanalyzedwithtwo-sampleMendelianrandomization(2SMR).MRanalysiswasconductedwithinverse-varianceweighting(IVW).Sensitivityanalysiswasperformedwithweightedmedian,MR-Eggerregression,Mendelianrandomizationpleiotropyresidualsumandoutlier(MR-PRESSO)tests.ResultsCoffeeintake(OR:0.994,95%CI:0.990-0.999,P=0.014)andgreenteaintake(OR:0.999,95%CI:0.998-0.999,P=0.036)werenegativelycorrelatedwiththeriskofPCa.Alcoholintake(OR:0.997,95%CI:0.990-1.004,P=0.392)anddairyintake(OR:1.025,95%CI:0.983-1.069,P=0.256)werenotassociatedwiththeriskofPCa.Inweightedmedian,MR-Eggerregression,andretentiononemethodanalyses,theresultswererobustwithoutheterogeneityorpleiotropy.ConclusionTherewasacausalassociationbetweencoffeeintakeandgreenteaintakeandtheonsetofPCa,butnocausalassociationbetweenalcoholintakeanddairyintakeandPCaonset.KEYWORDS:Mendelianrandomization;prostatecancer;causalinference;genome-wideassociationstudy;alcohol;coffee;greentea;dairyproducts摘要：目的采用两样本孟德尔随机化方法探究酒精、咖啡、绿茶和乳制品的摄入量与前列腺癌（PCa)发病之间是否存在因果关...
