临床医学研究与实践2023年10月第8卷第30期2型糖尿病（type2diabetesmellitus,T2DM）属于内分泌科常见疾病，由于机体胰岛素分泌不足或胰岛分泌功能紊乱，导致血糖水平逐渐升高，最终引起血管病变，致使心脏、肾脏等重要器官受损[1]。有研究显示，我国T2DM患者中有80%以上存在超重、肥胖，且随着腰围、体质量的增加及持续的高血糖状态，胰岛茁细胞功能受到损伤，对患者的血糖控制造成严重影响[2]。目前临床治疗主要采取运动疗法、并发症Effectofcanagliflozincombinedwithinsulininthetreatmentofobesetype2diabetesmellitusanditsinfluencesoninsulinresistanceandlipidmetabolismHEXiaoya,LIHaibin*(EndocrinologyDepartment,QishanCountyHospital,Baoji722400,China)ABSTRACT:ObjectiveToexploretheeffectofcanagliflozincombinedwithinsulininthetreatmentofobesetype2diabetesmellitus(T2DM)anditsinfluencesoninsulinresistanceandlipidmetabolism.MethodsAtotalof80obeseT2DMpatientsadmittedfromJanuary2019toOctober2021wereselectedastheresearchobjectsanddividedintocontrolgroupandobservationgroupaccordingtotherandomnumbertablemethod,with40casesineachgroup.Bothgroupsweregivenroutinetreatment,thecontrolgroupwastreatedwithinsulinonthebasisofroutinetreatment,andtheobservationgroupwastreatedwithcanagliflozinonthebasisofthecontrolgroup.Thetherapeuticeffectsofthetwogroupswerecompared.ResultsAftertreatment,themeanamplitudeofglycemicexcursions(MAGE),meanofdailydifferences(MODD),72hstandarddeviationofbloodglucose(SDBG),homeostasismodelassessmentofinsulinresistance(HOMA-IR),totalcholesterol(TC),triacylglycerol(TG),apolipoproteinB(ApoB),lowdensitylipoproteincholesterol(LDL-C)levels,waistcircumference(WC),bodymassindex(BMI)andvisceralfatarea(VFA)intheobservationgroupwerelowerthanthoseinthecontrolgroup,whilethehomeostasismodelassessmentof茁cellfunctionindex(HOMA-茁)andinsulinsensitivityindex(ISI)werehigherthanthoseofthecontrolgroup(P<0.05).ConclusionCanagliflozincombinedwithinsulininthetreatmentofobeseT2DMcanpromotetheeffectofbloodglucosecontrol,reduceinsulinresistanceandimprovelipidmetabolism,whichisworthyofpromotion.KEYWORDS:canagliflozin;insuli...
