《中华骨与关节外科杂志》2023年9月第16卷第9期ChinJBoneJointSurg,Vol.16,No.9,Sept.2023胫骨横向搬移技术的临床应用及其诱导血管再生机制的研究进展徐道非1,2，胡蓉2，余庆龙1，廖龙1，张滔1，余琳3，张定伟2，石波2【摘要】胫骨横向搬移技术通过诱导血管生成来治疗糖尿病足、动脉硬化闭塞症和血栓闭塞性脉管炎等下肢缺血性疾病。然而，尚未有明确的分子机制可以解释胫骨横向搬移技术与糖尿病足患者血管再生的关系。血管生成是一个重要的生物学过程，新血管形成对于糖尿病足患者伤口修复意义重大。胫骨横向搬移技术通过许多生物学机制来促进血运重建，如分泌促血管生成相关因子，诱导新血管形成；重建巨噬细胞极化平衡，以M2型为主，加速血管再生；激活相关细胞因子通路，促进骨髓间充质干细胞向血管生成-成骨耦合等。本文将对当前关于胫骨横向搬移技术的临床应用以及其直接或间接刺激血管生成的潜在驱动因素进行综述。【关键词】胫骨横向搬移技术；糖尿病足；血管再生；细胞因子【中图分类号】R687【文献标志码】A【文章编号】2095-9958（2023）09-0854-06DOI:10.3969/j.issn.2095-9958.2023.09.16ResearchprogressontheclinicalapplicationofthetibialtransversetransporttechniqueanditsangiogenesismechanismXUDaofei1,2,HURong2,YUQinglong1,LIAOLong1,ZHANGTao1,YULin3,ZHANGDingwei2,SHIBo21.ChengduMedicalCollege,Chengdu610500;2.DepartmentofOrthopaedics,MianyangCentralHospital,Mianyang621000,Sichuan;3.DepartmentofLaboratory,MianyangCentralHospital,Mianyang621000,Sichuan,ChinaCorrespondingAuthor:SHIBo,ZHANGDingwei【Abstract】Tibialtransversetransport(TTT)inducesangiogenesistotreatlowerextremityischemicdiseasessuchasdiabeticfoot,arteriosclerosisobliterans,andthromboangiitisobliterans.However,thereisnoclearmolecularmechanismthatcanexplaintherelationshipbetweenTTTandangiogenesisindiabeticfootpatients.Angiogenesisisanimportantbiologicalprocess,andneovascularizationisofgreatsignificanceforwoundrepairindiabeticfootpatients.TTTtechnologypromotesrevascularizationthroughmanybiologicalmechanisms,suchassecretingproangiogenicfactorstoinducenewbloodvesselformation,reconstructionofmacrophagepolarizationbalancewithM2macrophageasthemainfactorthatacceleratesangiogenesis,ac...
