综述第37卷第3期医学信息Vol.37No.32024年2月JournalofMedicalInformationFeb.2024作者简介:雷希君(1996.11-),女,湖北武汉人,硕士研究生,住院医师,主要从事胸腔灌注治疗临床研究通讯作者:罗利琼(1977.10-),女,湖北武汉人,博士,主任医师,硕士生导师,主要从事分子靶向治疗和免疫治疗腔内灌注治疗恶性胸腔积液的研究现状雷希君袁罗利琼渊武汉科技大学附属天佑医院肿瘤科袁湖北武汉430064冤摘要院恶性胸腔积液渊MPE冤是恶性肿瘤常见的相关并发症袁一旦出现就提示病情进入了恶化阶段袁临床治疗存在非常大的困难袁因常可伴随引起胸痛胸闷尧喘气等多种症状袁耐受力明显下降袁严重影响患者的生存质量及预后遥目前袁胸腔内直接局部灌注抗肿瘤药物的治疗方法应用较为广泛遥本文从胸膜硬化剂尧热疗尧化疗药物尧生物免疫抑制剂尧中药制剂尧抗血管生成剂及载药囊泡等方面入手袁分析各类药物的特点及临床应用袁以期为未来MPE的研究及治疗提供一定的参考依据遥关键词院灌注治疗曰恶性胸腔积液曰囊泡曰热疗曰恩度中图分类号院R734.3文献标识码院ADOI院10.3969/j.issn.1006-1959.2024.03.039文章编号院1006-1959渊2024冤03-0184-05ResearchStatusofIntracavitaryPerfusionintheTreatmentofMalignantPleuralEffusionLEIXi-jun,LUOLi-qiong(DepartmentofOncology,TianyouHospital,WuhanUniversityofScienceandTechnology,Wuhan430064,Hubei,China)Abstract:Malignantpleuraleffusion(MPE)isacommoncomplicationofmalignanttumors.Onceitoccurs,itindicatesthattheconditionhasenteredastageofdeterioration.Therearegreatdifficultiesinclinicaltreatment.Becauseitcanoftenbeaccompaniedbychestpain,chesttightness,wheezingandothersymptoms,thetoleranceissignificantlyreduced,whichseriouslyaffectsthequalityoflifeandprognosisofpatients.Atpresent,thetreatmentofintrapleuraldirectlocalperfusionofantitumordrugsiswidelyused.Inthispaper,thecharacteristicsandclinicalapplicationofvariousdrugsareanalyzedfromtheaspectsofpleuralsclerosingagent,hyperthermia,chemotherapeuticdrugs,biologicalimmunosuppressiveagents,traditionalChinesemedicinepreparations,anti-angiogenicagentsanddrug-loadedvesicles,inordertoprovidesomereferenceforthefutureresearchandtreatmentofMPE.Keywords:Perfusiontherapy;Malignantpleuraleff...