·病例报告·772024,14(1)医师在线第14卷第1期卵巢小细胞癌一例并文献复习尤悠1,2，李建奎2，易村犍1（1长江大学附属第一医院妇产科，湖北荆州434099；2中国人民解放军联勤保障部队第九六O医院妇科，济南250000）【摘要】目的探讨原发性卵巢小细胞癌（SCCO）的患病特点、诊断和临床治疗方案。方法报告1例SCCO患病情况并对国内外文献进行复习，分析其病理特征。结果SCCO起源组织尚不明确，70%患者伴高钙血症，恶性程度极高，几乎90%患者1年内死亡。结论SCCO发病极为罕见，病例报告非常少，临床可供参考资料有限。目前尚无明确治疗指南，参考卵巢癌常规肿瘤细胞减灭术后辅以化疗、放疗方案仍是目前的治疗手段，不管何种治疗，本病预后均差，联合治疗（特别是接受高剂量化疗后）可能会延长生存时间。根据基因检测，制定个性化的治疗方案，对于提高患者生存率具有重要意义。【关键词】卵巢小细胞癌；化疗；基因突变Smallcellmalignanttumorofovary:acasereportandliteraturereviewYOUYou*,LIJian-kui,YICun-jian.*Departmentofobstetricsandgynecology,TheFirstAtfiliatedHospitalofYangtzeUniversity,Jingzhou434099;The960thHospitaloftheChinesePeople'sLiberationArmyJointLogisticSupportForce,Jinan250000,China.【Abstract】ObjectiveToinvestigatethecharacteristics,diagnosisandclinicaltreatmentofprimarysmallcellcarcinomaoftheovary(SCCO).Methods1caseofSCCOwasreportedandtheliteratureathomeandabroadwasreviewedtoanalyzeitspathologicalfeatures.ResultsTheoriginofSCCOwasnotclear.70%patientshadhypercalcemia.Thedegreeofmalignancywasextremelyhigh,andalmost90%ofthepatientsdiedwithin1year.ConclusionTheincidenceofSCCOisextremelyrare,andthereareveryfewcasesreported.Atpresent,therearenocleartreatmentguidelines,referringtotheroutinetumorcellreductionofovariancancersupplementedbychemotherapyandradiotherapyisstillthecurrenttreatment.Regardlessofthetreatment,theprognosisofthisdiseaseispoor,andcombinedtherapy(especiallyafterreceivinghigh-dosechemotherapy)mayprolongthesurvivaltime.Accordingtothegeneticexamination,thedevelopmentofpersonalizedtreatmentplanisofgreatsignificancetoimprovethesurvivalrateofpatients.【Keywords】Smallcellmalignanttumorsofovary;Chemotherapy;Genemutation...
