紧密连接蛋白claudin-10功能的研究进展*何柳,丛馨△(北京大学基础医学院生理学与病理生理学系,北京100191)摘要Claudin-10是紧密连接跨膜蛋白claudin家族的一员,在多个器官和组织的上皮细胞中表达,存在claudin-10a与10b两种同工型。Claudin-10具有维持细胞膜选择透过性和调节离子经旁细胞途径转运的作用。近年来,claudin-10已被报道与多种疾病的发生发展过程相关。Claudin-10基因突变导致的多种器官功能受损的疾病被命名为HELIX综合征,患者具有无汗症、肾病、低钾血症、口干症及严重的牙釉质磨损等临床表现。本文将对claudin-10的分子结构、表达与分布、功能与疾病关系等方面的研究进展进行综述。关键词claudin-10;紧密连接;旁细胞途径;HELIX综合征中图分类号R363;R393ResearchProgressontheFunctionofTightJunctionProteinClaudin-10*HELiu,CONGXin△(DepartmentofPhysiologyandPathophysiology,SchoolofBasicMedicalSciences,PekingUniversityHealthScienceCenter,Beijing100191,China)AbstractClaudin-10,amemberoftheclaudinfamilyoftightjunctiontransmembraneproteins,isexpressedinepithelialcellsofmultipleorgansandtissues,withtwoisoforms,claudin-10aandclaudin-10b.Itplaysacriticalroleinmaintainingtheselectivepermeabilityofcellmembraneandregulatingiontransportthroughtheparacellularpathway.Inrecentyears,claudin-10hasbeenreportedtobeassociatedwiththedevelopmentandprogressionofavarietyofdiseases.Diseasescharacterizedbyimpairedfunctionofmultipleorgansduetomutationsintheclaudin-10genearecollectivelyreferredtoasHELIXsyndrome,whichgenerallyresultsinclinicalmanifestationssuchasanhidrosis,renaldisease,hypokalemia,xerostomia,andsevereenamelwear.Inthisre-view,theresearchprogressonclaudin-10willbepresented,includingitsmolecularstructure,expressionanddistribution,aswellastherelationshipbetweenclaudin-10functionanddiseases.Keywordsclaudin-10;tightjunction;paracellularpathway;HELIXsyndrome引用格式:何柳,丛馨.紧密连接蛋白claudin-10功能的研究进展.生理科学进展,2023,54(5)︰445~450.HELiu,CONGXin.ResearchProgressontheFunctionofTightJunctionProteinClaudin-10.ProgressinPhysiologicalSciences,2023,54(5)︰445~450.DOI︰10.20059/j.cnki.pps.2023.04.1125细胞间连接是存在于...
