SYSTEMSMEDICINE系统医学系统医学2023年8月第8卷第15期·临床医学系统研究·结核分枝杆菌分子生物检测与常规痰涂片检验结核菌的临床比较葛冰磊，陈永红，徐成春，赵成娟宣城市人民医院检验科，安徽宣城242000[摘要]目的探讨对比结核分枝杆菌分子生物检测与常规痰涂片检验结核菌的临床价值。方法选取2020年1月—2022年12月期间宣城市人民医院收治的248例疑似结核患者，均进行结核分枝杆菌分子生物检测与常规痰涂片检验，以罗氏固体培养基培养结果作为金标准，对其阳性检出率及诊断效能等进行比较。结果结核分枝杆菌分子生物检测的阳性检出率（35.89%）高于常规痰涂片（33.06%）；结核分枝杆菌分子生物检测的灵敏度94.19%、特异度95.06%高于常规痰涂片82.56%和93.21%，但差异无统计学意义（χ2=0.949、0.077，P>0.05）。结论结核分枝杆菌分子生物检测结核菌其检出率高，且进一步提高其诊断效能，一致性良好，可为疑似结核的患者提供明确诊断，对后续疾病治疗及控制提供重要参考。[关键词]结核分枝杆菌分子生物检测；常规痰涂片；结核菌；临床比较[中图分类号]R446[文献标识码]A[文章编号]2096-1782（2023）08(a)-0091-05ClinicalComparisonofMolecularBioassayforMycobacteriumTuberculo⁃siswithRoutineSputumSmearTestingforTubercleBacilliGEBinglei,CHENYonghong,XUChengchun,ZHAOChengjuanDepartmentofLaboratory,XuanchengPeople'sHospital,Xuancheng,AnhuiProvince,242000China[Abstract]ObjectiveToinvestigatetheclinicalvalueofcomparingmolecularbiologicaltestingforMycobacteriumtu⁃berculosiswithroutinesputumsmeartestingformycobacteriumtuberculosis.MethodsAtotalof248suspectedtuber⁃culosispatientsadmittedtoXuanchengPeople'sHospitalbetweenJanuary2020andDecember2022wereselected,andallofthemweresubjectedtomycobacteriumtuberculosismolecularbiologytestandroutinesputumsmeartest,andtheresultsofrochesolidmediumculturewereusedasthegoldstandardtocomparethepositivedetectionrateanddiagnosticefficacy.ResultsThepositivedetectionrateofmycobacteriumtuberculosismolecularbioassay(35.89%)washigherthanconventionalsputumsmear(33.06%).Thesensitivityandspecificityofmycobacteriumtu⁃berculosismolecularbioassaywere94.19%and95.06%,whichweresignificantlyhigherthanconventionalsputumsmear82.56%and...
