论著拉莫三嗪联合托吡酯治疗癫痫患儿的临床疗效及其对患者认知功能、神经因子水平的影响陈静杨菊萍靳红光赵丹(焦作市第二人民医院,河南焦作４５４０００)[摘要]【目的】探讨拉莫三嗪联合托吡酯治疗癫痫患儿的临床疗效及其对患者认知功能、神经因子水平的影响.【方法】回顾性分析２０２１年２月至２０２２年１２月本院收治的５６例癫痫患儿的临床资料,根据治疗方案的不同将患儿分为对照组(拉莫三嗪治疗)、观察组(拉莫三嗪＋托吡酯治疗),每组２８例.比较两组临床疗效、脑电图疗效、治疗前及治疗后发作情况、神经因子[神经肽Y(NPY)、胰岛素样生长因子１(IGFＧ１)、脑源性神经营养因子(BDNF)、细胞间黏附分子Ｇ１(ICAMＧ１)]水平、认知功能[韦氏智力量表(WISCＧⅣ)评分]、焦虑及抑郁情绪[汉密尔顿焦虑量表(HAMA)及抑郁量表(HAMD)评分].【结果】观察组临床有效率、脑电图总有效率高于对照组,差异有统计学意义(P＜０．０５).治疗后,两组发作频率及发作持续时间均少于治疗前,且观察组少于对照组,差异有统计学意义(P＜０．０５).治疗后,观察组WISCＧⅣ评分高于对照组,HAMA、HAMD评分低于对照组(P＜０．０５).治疗后,两组血清NPY、IGFＧ１、BDNF、ICAMＧ１水平低于治疗前,且观察组低于对照组,差异有统计学意义(P＜０．０５).【结论】拉莫三嗪联合托吡酯治疗小儿癫痫临床疗效较好,可减少发作次数,促进神经功能恢复,改善认知功能,缓解焦虑、抑郁情绪.[关键词]癫痫/药物治疗;拉莫三嗪/药理学;托吡酯/药理学;认知;活化白细胞黏附分子TheClinicalEfficacyofLamotrigineCombinedwithTopiramateintheTreatmentofChildrenwithEpilepsyanditsImpactonCognitiveFunctionandNeurotrophicFactorLevelsinPatientsCHENJing,YANGJuping,JINHongguang,etal(TheSecondHospitalofJiaozuo,JiaozuoHenan４５４０００)[Abstract]【Objective】ToexploretheclinicalefficacyoflamotriginecombinedwithtopiramateinthetreatmentofchilＧdrenwithepilepsyanditsimpactoncognitivefunctionandneurotrophicfactorlevelsinpatients．【Methods】Aretrospectiveanalysiswasconductedontheclinicaldataof５６childrenwithepilepsyadmittedtoourhospitalfromFebruary２０２１toDeＧcember２０２２．Accordingtodifferenttreatmentplans,thechildrenweredividedintoacontrolgroup(treatedwithlamotrigiＧne)andanobservationgroup(treatedwithlamotrigineandtopiramate),with２８casesin...
