医学检验与临床2024年第35卷第2期MedicalLaboratoryScienceandClinics,2024,Vol.35,No.2·5doi:10.3969/j.issn.1673-5013.2024.02.002sST2、hs-CRP和NT-proBNP三指标联合对小儿肺炎合并心衰的诊断价值一江润深1走赵东1饶雪飞1杨锐强1陈强锋21（佛山复星禅诚医院检验科，广东佛山528000)2（佛山复星禅诚医院儿科，广东佛山528000）[摘要]目的：探讨sST2、hs-CRP、NT-proBNP三指标联合对小儿肺炎合并心衰的诊断价值。方法：43例肺炎并心衰患者为观察组，45例体检健康儿作为对照组，所有对象均检测血清sST2、hsCRP、NT-proBNP浓度，对比两组的检测指标。结果：经分析，三指标在两组间的差异具有统计学意义（P<0.05)；ROC曲线分析显示三指标联合检测的AUC优于单独检测；Logistic回归表明，sST2、hs-CRP、NT-proBNP是小儿肺炎并心力衰竭的独立影响因素。结论：sST2、hs-CRP、NT-proBNP可用于小儿肺炎合并心力衰竭的诊断，且三指标联合检测有利于提高诊断价值。[关键词]sST2；NT-proBNP；小儿肺炎并心衰DiagnosticvalueofsST2、hs-CRPandNT-proBNPinpediatricpneumoniacomplicatedwithheartfailureJIANGRun-shen,ZHAODong,RAOXue-fei,etal(Clinicallaboratory,FoshanFosunChanchengHospital,GuangdongFoshan528000)[Abstract]Objective:ExporethediagnosticvalueofsST2、hs-CRPandNT-proBNPinpediatricpneumoniawithheartfailure.Methods:Forty-threepatientswithpneumoniaandheartfailurewereastheobservationgroup,and45healthyinfantswereusedasthecontrolgroup,sST2、hsCRPandNT-proBNPweredetectedinallsubjects,andthedetectionindexesofthetwogroupswerecompared.Results:Thethreetesteditemsdisplayedsignificantdifferencesbetweenthegroups(P<0.05);ROCcurveanalysisdisplayedthattheAUCofthecombineddetectionofthethreeindexeswashigherthansingledetection;LogisticregressionshowedthatsST2,hs-CRP,NT-proBNPwereindependentinfluencingfactorsofpediatricpneumoniawithheartfailure.Conclusion:sST2、hs-CRPandNT-proBNPcouldbeusedinthediagnosisofpediatricpneumoniawithheartfailure,andthecombineddetectionofthreeindicatorscouldimprovethediagnosticvalue.[KeyWords]sST2;NT-proBNP;Pediatricpneumoniawithheartfailure肺炎是儿科常见病，重症肺炎死亡率高达30%，是5岁以下婴幼儿死亡的主要因素。心衰表现为呼吸困难、乏力、液体潴...
