·30·医药前沿2024年1月第14卷第1期综述基于肠道菌群探讨从脾虚论治糖尿病胃轻瘫刘美汐1，罗富锟2，李雯1，李清1，田雨婷1，陈秋3（通信作者）（1成都中医药大学临床医学院四川成都610075）（2中国中医科学院广安门医院心血管科北京100000）（3成都中医药大学附属医院内分泌科四川成都610075）【摘要】糖尿病胃轻瘫（DGP）为常见的糖尿病并发症，其特征是在没有机械性梗阻的情况下出现胃排空延迟。根据其临床症候特点，中医学将DGP归属于“痞满”“腹胀”“呕吐”等范畴。基于前期文献梳理，团队发现DGP的发生发展与肠道菌群紧密联系，而脾虚是胃轻瘫的关键中医病机。因此，本研究从DGP的肠道菌群病生理机制与脾虚关键病机出发，阐释三者内在关联，进而提出通过健脾益气法可基于调节肠道菌群对DGP起到积极治疗作用。同时，本文还探讨了单味中药、中药复方以及针灸在其中的运用，以期为构筑肠道菌群学说与健脾益气治法指导下的DGP中医药治疗策略提供借鉴。【关键词】综述；糖尿病；胃轻瘫；肠道菌群；脾虚【中图分类号】R574【文献标识码】A【文章编号】2095-1752（2024）01-0030-04TraditionalChineseMedicinetreatmentofdiabeticgastroparesisfromspleendeficiencybasedongutmicrobiotaLIUMeixi1,LUOFukun2,LIWen1,LIQing1,TIANYuting1,CHENQiu3(Correspondingauthor)1SchoolofClinicalMedicine,ChengduUniversityofTraditionalChineseMedicine,Chengdu,Sichuan610075,China2DepartmentofCardiovascularMedicine,Guang'anmenHospital,ChinaAcademyofChineseMedicalSciences,Beijing100000,China3DepartmentofEndocrinology,AffiliatedHospitalofChengduUniversityofTraditionalChineseMedicine,Chengdu,Sichuan610075,China【Abstract】Diabeticgastroparesis(DGP)isacommoncomplicationofdiabetescharacterizedbydelayedgastricemptyingintheabsenceofmechanicalobstruction.Accordingtoitsclinicalmanifestations,TraditionalChineseMedicine(TCM)categorizesDGPwithintherealmsof'piman'(abdominaldistention),'fuzhang'(abdominalfullness),and'outu'(vomiting).Basedonareviewofpriorliterature,theteamdiscoveredacloseassociationbetweentheoccurrenceandprogressionofDGPandtheintestinalmicrobiota,with'spleendeficiency'beingakeyTCMpathologicalfactorinDGP.Therefore,thisstudyelucidatestheintrinsicconnectionsamongtheintestinal...
